Terpenoids from Vitex trifolia and their anti-inflammatory activities
A new diterpenoid glucoside, (3 S ,5 S ,6 S ,8 R ,9 R ,10 S )-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3- O - β -D-glucopyranoside ( 1 ), and a new iridoid glucoside, (1 S , 5 S ,6 R ,9 R )-10- O - p -hydroxybenzoyl-5,6 β -dihydroxy iridoid 1- O - β -D-glucopyranoside ( 2 ), along with six known...
Gespeichert in:
| Veröffentlicht in: | Journal of natural medicines 2018-03, Vol.72 (2), p.570-575 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 575 |
|---|---|
| container_issue | 2 |
| container_start_page | 570 |
| container_title | Journal of natural medicines |
| container_volume | 72 |
| creator | Bao, Fengyan Tang, Ruotian Cheng, Li Zhang, Cuiyun Qiu, Chongyue Yuan, Ting Zhu, Lihan Li, Hua Chen, Lixia |
| description | A new diterpenoid glucoside, (3
S
,5
S
,6
S
,8
R
,9
R
,10
S
)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-
O
-
β
-D-glucopyranoside (
1
), and a new iridoid glucoside, (1
S
, 5
S
,6
R
,9
R
)-10-
O
-
p
-hydroxybenzoyl-5,6
β
-dihydroxy iridoid 1-
O
-
β
-D-glucopyranoside (
2
), along with six known compounds (
3-8
) were isolated from
Vitex trifolia
L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds
2
,
4
,
5
, and
7
showed moderate inhibitory activities with IC
50
values of 90.05, 88.51, 87.26, and 76.06
μ
M, respectively. |
| doi_str_mv | 10.1007/s11418-018-1178-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2001407949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2001407949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-e5cd92f8cd7e2f6d2e9c47b86df5915e49c3be6538657309756b5ba7b936e4793</originalsourceid><addsrcrecordid>eNp1kEtLAzEQx4MotlY_gBdZ8OJlNc_N5iilPqDgpXoN2d1ZTdlHTbLSfntT1gcIHoYZyG_-E34InRN8TTCWN54QTvIUxyJE5un2AE1JnpEUU8UO48w4ThnnbIJOvF9jzClj5BhNqOJUYaGmaLECt4Gut5VPate3yYsNsE2Cs3XfWJOYrkrCG1gXp2BT29WNaVsTerdLTBnshw0W_Ck6qk3j4eyrz9Dz3WI1f0iXT_eP89tlWjKVhRREWSla52UlgdZZRUGVXBZ5VtVCEQFclayATLA8E5JhJUVWiMLIQrEMuFRshq7G3I3r3wfwQbfWl9A0poN-8JpiTDiWiu_Ryz_ouh9cF38XKSJyqQgVkSIjVbreewe13jjbGrfTBOu9Yz061tGx3jvW27hz8ZU8FC1UPxvfUiNAR8DHp-4V3O_p_1M_ARQQhuo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2015879125</pqid></control><display><type>article</type><title>Terpenoids from Vitex trifolia and their anti-inflammatory activities</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bao, Fengyan ; Tang, Ruotian ; Cheng, Li ; Zhang, Cuiyun ; Qiu, Chongyue ; Yuan, Ting ; Zhu, Lihan ; Li, Hua ; Chen, Lixia</creator><creatorcontrib>Bao, Fengyan ; Tang, Ruotian ; Cheng, Li ; Zhang, Cuiyun ; Qiu, Chongyue ; Yuan, Ting ; Zhu, Lihan ; Li, Hua ; Chen, Lixia</creatorcontrib><description>A new diterpenoid glucoside, (3
S
,5
S
,6
S
,8
R
,9
R
,10
S
)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-
O
-
β
-D-glucopyranoside (
1
), and a new iridoid glucoside, (1
S
, 5
S
,6
R
,9
R
)-10-
O
-
p
-hydroxybenzoyl-5,6
β
-dihydroxy iridoid 1-
O
-
β
-D-glucopyranoside (
2
), along with six known compounds (
3-8
) were isolated from
Vitex trifolia
L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds
2
,
4
,
5
, and
7
showed moderate inhibitory activities with IC
50
values of 90.05, 88.51, 87.26, and 76.06
μ
M, respectively.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-018-1178-x</identifier><identifier>PMID: 29429059</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Complementary & Alternative Medicine ; Herbal medicine ; Medicinal Chemistry ; Nitric oxide ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Extracts - chemistry ; Plant Sciences ; Terpenes - chemistry ; Vitex - chemistry</subject><ispartof>Journal of natural medicines, 2018-03, Vol.72 (2), p.570-575</ispartof><rights>The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-e5cd92f8cd7e2f6d2e9c47b86df5915e49c3be6538657309756b5ba7b936e4793</citedby><cites>FETCH-LOGICAL-c396t-e5cd92f8cd7e2f6d2e9c47b86df5915e49c3be6538657309756b5ba7b936e4793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-018-1178-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-018-1178-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29429059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bao, Fengyan</creatorcontrib><creatorcontrib>Tang, Ruotian</creatorcontrib><creatorcontrib>Cheng, Li</creatorcontrib><creatorcontrib>Zhang, Cuiyun</creatorcontrib><creatorcontrib>Qiu, Chongyue</creatorcontrib><creatorcontrib>Yuan, Ting</creatorcontrib><creatorcontrib>Zhu, Lihan</creatorcontrib><creatorcontrib>Li, Hua</creatorcontrib><creatorcontrib>Chen, Lixia</creatorcontrib><title>Terpenoids from Vitex trifolia and their anti-inflammatory activities</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>A new diterpenoid glucoside, (3
S
,5
S
,6
S
,8
R
,9
R
,10
S
)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-
O
-
β
-D-glucopyranoside (
1
), and a new iridoid glucoside, (1
S
, 5
S
,6
R
,9
R
)-10-
O
-
p
-hydroxybenzoyl-5,6
β
-dihydroxy iridoid 1-
O
-
β
-D-glucopyranoside (
2
), along with six known compounds (
3-8
) were isolated from
Vitex trifolia
L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds
2
,
4
,
5
, and
7
showed moderate inhibitory activities with IC
50
values of 90.05, 88.51, 87.26, and 76.06
μ
M, respectively.</description><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Complementary & Alternative Medicine</subject><subject>Herbal medicine</subject><subject>Medicinal Chemistry</subject><subject>Nitric oxide</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Sciences</subject><subject>Terpenes - chemistry</subject><subject>Vitex - chemistry</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLAzEQx4MotlY_gBdZ8OJlNc_N5iilPqDgpXoN2d1ZTdlHTbLSfntT1gcIHoYZyG_-E34InRN8TTCWN54QTvIUxyJE5un2AE1JnpEUU8UO48w4ThnnbIJOvF9jzClj5BhNqOJUYaGmaLECt4Gut5VPate3yYsNsE2Cs3XfWJOYrkrCG1gXp2BT29WNaVsTerdLTBnshw0W_Ck6qk3j4eyrz9Dz3WI1f0iXT_eP89tlWjKVhRREWSla52UlgdZZRUGVXBZ5VtVCEQFclayATLA8E5JhJUVWiMLIQrEMuFRshq7G3I3r3wfwQbfWl9A0poN-8JpiTDiWiu_Ryz_ouh9cF38XKSJyqQgVkSIjVbreewe13jjbGrfTBOu9Yz061tGx3jvW27hz8ZU8FC1UPxvfUiNAR8DHp-4V3O_p_1M_ARQQhuo</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Bao, Fengyan</creator><creator>Tang, Ruotian</creator><creator>Cheng, Li</creator><creator>Zhang, Cuiyun</creator><creator>Qiu, Chongyue</creator><creator>Yuan, Ting</creator><creator>Zhu, Lihan</creator><creator>Li, Hua</creator><creator>Chen, Lixia</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Terpenoids from Vitex trifolia and their anti-inflammatory activities</title><author>Bao, Fengyan ; Tang, Ruotian ; Cheng, Li ; Zhang, Cuiyun ; Qiu, Chongyue ; Yuan, Ting ; Zhu, Lihan ; Li, Hua ; Chen, Lixia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-e5cd92f8cd7e2f6d2e9c47b86df5915e49c3be6538657309756b5ba7b936e4793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Complementary & Alternative Medicine</topic><topic>Herbal medicine</topic><topic>Medicinal Chemistry</topic><topic>Nitric oxide</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Sciences</topic><topic>Terpenes - chemistry</topic><topic>Vitex - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bao, Fengyan</creatorcontrib><creatorcontrib>Tang, Ruotian</creatorcontrib><creatorcontrib>Cheng, Li</creatorcontrib><creatorcontrib>Zhang, Cuiyun</creatorcontrib><creatorcontrib>Qiu, Chongyue</creatorcontrib><creatorcontrib>Yuan, Ting</creatorcontrib><creatorcontrib>Zhu, Lihan</creatorcontrib><creatorcontrib>Li, Hua</creatorcontrib><creatorcontrib>Chen, Lixia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bao, Fengyan</au><au>Tang, Ruotian</au><au>Cheng, Li</au><au>Zhang, Cuiyun</au><au>Qiu, Chongyue</au><au>Yuan, Ting</au><au>Zhu, Lihan</au><au>Li, Hua</au><au>Chen, Lixia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Terpenoids from Vitex trifolia and their anti-inflammatory activities</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>72</volume><issue>2</issue><spage>570</spage><epage>575</epage><pages>570-575</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>A new diterpenoid glucoside, (3
S
,5
S
,6
S
,8
R
,9
R
,10
S
)-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3-
O
-
β
-D-glucopyranoside (
1
), and a new iridoid glucoside, (1
S
, 5
S
,6
R
,9
R
)-10-
O
-
p
-hydroxybenzoyl-5,6
β
-dihydroxy iridoid 1-
O
-
β
-D-glucopyranoside (
2
), along with six known compounds (
3-8
) were isolated from
Vitex trifolia
L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds
2
,
4
,
5
, and
7
showed moderate inhibitory activities with IC
50
values of 90.05, 88.51, 87.26, and 76.06
μ
M, respectively.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>29429059</pmid><doi>10.1007/s11418-018-1178-x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-3443 |
| ispartof | Journal of natural medicines, 2018-03, Vol.72 (2), p.570-575 |
| issn | 1340-3443 1861-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2001407949 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomedical and Life Sciences Biomedicine Complementary & Alternative Medicine Herbal medicine Medicinal Chemistry Nitric oxide Pharmacology/Toxicology Pharmacy Phytochemicals Plant Extracts - chemistry Plant Sciences Terpenes - chemistry Vitex - chemistry |
| title | Terpenoids from Vitex trifolia and their anti-inflammatory activities |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T17%3A50%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Terpenoids%20from%20Vitex%20trifolia%20and%20their%20anti-inflammatory%20activities&rft.jtitle=Journal%20of%20natural%20medicines&rft.au=Bao,%20Fengyan&rft.date=2018-03-01&rft.volume=72&rft.issue=2&rft.spage=570&rft.epage=575&rft.pages=570-575&rft.issn=1340-3443&rft.eissn=1861-0293&rft_id=info:doi/10.1007/s11418-018-1178-x&rft_dat=%3Cproquest_cross%3E2001407949%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2015879125&rft_id=info:pmid/29429059&rfr_iscdi=true |