Strategy To Prepare 3‑Bromo- and 3‑Chloropyrazoles
A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable...
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| Veröffentlicht in: | Journal of organic chemistry 2018-03, Vol.83 (5), p.2830-2839 |
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| container_end_page | 2839 |
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| container_issue | 5 |
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| container_title | Journal of organic chemistry |
| container_volume | 83 |
| creator | Fox, Richard J Schmidt, Michael A Eastgate, Martin D |
| description | A general strategy to prepare substituted 3-bromo- and 3-chloropyrazoles is described. The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. Several condensation and oxidation protocols were developed to enable preparation of a wide variety of 3-halopyrazoles with good to excellent yields and regiocontrol. |
| doi_str_mv | 10.1021/acs.joc.7b03282 |
| format | Article |
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The three-step method involves condensation of crotonates or β-chloro carboxylic acids with hydrazines, followed by halogenation and oxidation. 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| ispartof | Journal of organic chemistry, 2018-03, Vol.83 (5), p.2830-2839 |
| issn | 0022-3263 1520-6904 |
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| title | Strategy To Prepare 3‑Bromo- and 3‑Chloropyrazoles |
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