CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes

There is evidence that cancer stem-like cells (CSC) and neuroendocrine behavior play critical roles in the pathogenesis and clinical course of metastatic castration-resistant prostate cancer (m-CRPC). However, there is limited mechanistic understanding of how CSC and neuroendocrine phenotypes impact...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-04, Vol.78 (8), p.2026-2039
Hauptverfasser:	Jung, Younghun, Cackowski, Frank C, Yumoto, Kenji, Decker, Ann M, Wang, Jingcheng, Kim, Jin Koo, Lee, Eunsohl, Wang, Yugang, Chung, Jae-Seung, Gursky, Amy M, Krebsbach, Paul H, Pienta, Kenneth J, Morgan, Todd M, Taichman, Russell S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - secondary Castration Cell Line, Tumor Cell Proliferation - physiology Cellular Reprogramming Chemokine CXCL12 - physiology Chemoresistance CXCR4 protein Heterografts Humans Male Metastases Metastasis Mice, SCID Neoplastic Stem Cells - pathology Neuroendocrine Cells - pathology NF-kappa B - metabolism NF-κB protein Phenotype Phenotypes Prostate cancer Prostatic Neoplasms, Castration-Resistant - pathology Protein kinase C Protein Kinase C-alpha - metabolism Receptors, CXCR4 - metabolism Signal Transduction Stem cells Therapeutic applications Tumor cells
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