Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis

Heat shock protein (Hsp) 90 inhibitors, such as 17-allylamino-17-demethoxy-geldanamycin (17-AAG), constitute promising novel therapeutic agents. We investigated the anti-inflammatory activity of 17-AAG in endotoxin-induced uveitis (EIU) in rats. After the induction of EIU with a footpad injection of...

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Veröffentlicht in:	The FASEB journal 2007-07, Vol.21 (9), p.2113-2123
Hauptverfasser:	Poulaki, Vassiliki, Iliaki, Eirini, Mitsiades, Nicholas, Mitsiades, Constantine S, Paulus, Yiannis N, Bula, Deisy V, Gragoudas, Evangelos S, Miller, Joan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Bacterial Toxins - toxicity Benzoquinones - therapeutic use Blood-Retinal Barrier - drug effects Cell Adhesion - drug effects Cell Membrane - chemistry Drug Evaluation, Preclinical EIU Endotoxins - toxicity HSP90 Heat-Shock Proteins - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - metabolism inflammatory eye disease Interleukin-1beta - biosynthesis Interleukin-1beta - blood Lactams, Macrocyclic - therapeutic use Leukocytes - chemistry Leukostasis - etiology Leukostasis - prevention & control lipopolysaccharide Lipopolysaccharide Receptors - blood Male Membrane Proteins - metabolism NF-kappa B - metabolism Occludin p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Phosphorylation - drug effects Protein Processing, Post-Translational - drug effects Rats Rats, Long-Evans Retinal Vasculitis - chemically induced Retinal Vasculitis - prevention & control Signal Transduction - drug effects Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - biosynthesis Up-Regulation - drug effects Uveitis, Anterior - chemically induced Uveitis, Anterior - drug therapy Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - blood Zonula Occludens-1 Protein
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