Transcriptional and splicing dysregulation in the prefrontal cortex in valproic acid rat model of autism

•Acute postnatal exposure to VPA induced autism-like behaviors.•VPA could affect transcriptional and splicing events genome-wide.•Dysregulated genes are associated with neurological diseases and neural system development. Gene-environmental interaction could be the major cause of autism. The aim of...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2018-04, Vol.77, p.53-61
Hauptverfasser:	Zhang, Ruoxin, Zhou, Jinlong, Ren, Junrong, Sun, Siqi, Di, Yuanyuan, Wang, Hanyu, An, Xiaoqin, Zhang, Kexin, Zhang, Junfeng, Qian, Zhaoqiang, Shi, Meimei, Qiao, Yanning, Ren, Wei, Tian, Yingfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing gene Autism RNA sequencing (RNA-seq) Transcriptome Valproic acid (VPA)
Online-Zugang:	Volltext
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