Hyperpolarization by N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes

To study the adverse effects of N-(3-oxododecanoyl)-l-homoserine-lactone (ODHL), a quorum sensing molecule, on mammalian host cells, its effect on membrane potential was examined in rat thymic lymphocytes using flow cytometric techniques with a voltage-sensitive fluorescent probe. As 3–300 μM ODHL e...

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Veröffentlicht in:	Chemico-biological interactions 2018-03, Vol.283, p.91-96
Hauptverfasser:	Nishimura-Danjobara, Yumiko, Oyama, Keisuke, Yokoigawa, Kumio, Oyama, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - pharmacology Animals Calcium - metabolism Cell Polarity - drug effects Charybdotoxin - pharmacology Flow Cytometry Glyburide - pharmacology Homoserine - analogs & derivatives Homoserine - pharmacology K+ channels KATP Channels - metabolism Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Membrane K+ permeability Membrane potential N-(3-oxododecanoyl)-l-homoserine-Lactone Permeability - drug effects Potassium - metabolism Potassium Channels, Voltage-Gated - metabolism Quinine - pharmacology Quorum Sensing - drug effects Rats Rats, Wistar Thymocytes - cytology
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