Effectiveness of an Ayurveda treatment approach in knee osteoarthritis – a randomized controlled trial
Ayurveda is commonly used in South Asia to treat knee osteoarthritis (OA). We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional conservative care in patients with knee OA. According to American College of Rheumatology (ACR) criteria knee OA patients were included in...
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| Veröffentlicht in: | Osteoarthritis and cartilage 2018-05, Vol.26 (5), p.620-630 |
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| creator | Kessler, C.S. Dhiman, K.S. Kumar, A. Ostermann, T. Gupta, S. Morandi, A. Mittwede, M. Stapelfeldt, E. Spoo, M. Icke, K. Michalsen, A. Witt, C.M. |
| description | Ayurveda is commonly used in South Asia to treat knee osteoarthritis (OA). We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional conservative care in patients with knee OA.
According to American College of Rheumatology (ACR) criteria knee OA patients were included in a multicenter randomized, controlled, open-label trial and treated in 2 hospital clinics and 2 private outpatient clinics in Germany. Participants received either a multi-modal Ayurvedic treatment or multi-modal conventional care with 15 treatments over 12 weeks respectively. Primary outcome was the change on the Western Ontario and McMaster University Osteoarthritis (WOMAC) Index after 12 weeks. Secondary outcomes included WOMAC subscales; the pain disability index and a pain experience scale, numeric rating scales for pain and sleep quality, quality-of-life and mood, rescue medication use, and safety issues.
One hundred fifty-one participants (Ayurveda n = 77, conventional care n = 74) were included. Changes of the WOMAC Index from baseline to 12 weeks were more pronounced in the Ayurveda group (mean difference 61.0 [95%CI: 52.4;69.6]) than in the conventional group (32.0 [95%CI: 21.4;42.6]) resulting in a significant between-group difference (p |
| doi_str_mv | 10.1016/j.joca.2018.01.022 |
| format | Article |
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According to American College of Rheumatology (ACR) criteria knee OA patients were included in a multicenter randomized, controlled, open-label trial and treated in 2 hospital clinics and 2 private outpatient clinics in Germany. Participants received either a multi-modal Ayurvedic treatment or multi-modal conventional care with 15 treatments over 12 weeks respectively. Primary outcome was the change on the Western Ontario and McMaster University Osteoarthritis (WOMAC) Index after 12 weeks. Secondary outcomes included WOMAC subscales; the pain disability index and a pain experience scale, numeric rating scales for pain and sleep quality, quality-of-life and mood, rescue medication use, and safety issues.
One hundred fifty-one participants (Ayurveda n = 77, conventional care n = 74) were included. Changes of the WOMAC Index from baseline to 12 weeks were more pronounced in the Ayurveda group (mean difference 61.0 [95%CI: 52.4;69.6]) than in the conventional group (32.0 [95%CI: 21.4;42.6]) resulting in a significant between-group difference (p < 0.001) and a clinically relevant effect size (Cohen's d 0.68 [95% CI:0.35;1.01]). Similar trends were observed for all secondary outcomes at week 12. Effects were sustained at follow-ups after 6 and 12 months.
Results suggest that Ayurvedic treatment is beneficial in reducing knee OA symptoms. Further studies should be conducted to confirm the magnitude of the effect and to clarify the role of different treatment components and non-specific effects.
at clinicaltrials.gov (NCT01225133; initial release 10/06/2010).</description><identifier>ISSN: 1063-4584</identifier><identifier>EISSN: 1522-9653</identifier><identifier>DOI: 10.1016/j.joca.2018.01.022</identifier><identifier>PMID: 29426006</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Ayurveda ; Complementary medicine ; Integrative medicine ; Knee osteoarthritis</subject><ispartof>Osteoarthritis and cartilage, 2018-05, Vol.26 (5), p.620-630</ispartof><rights>2018 The Author(s)</rights><rights>Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-335da940ebf7ccfb86214e5b1cb8414cf1f093f63ce1d391e8f2109f35c851203</citedby><cites>FETCH-LOGICAL-c400t-335da940ebf7ccfb86214e5b1cb8414cf1f093f63ce1d391e8f2109f35c851203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joca.2018.01.022$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29426006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kessler, C.S.</creatorcontrib><creatorcontrib>Dhiman, K.S.</creatorcontrib><creatorcontrib>Kumar, A.</creatorcontrib><creatorcontrib>Ostermann, T.</creatorcontrib><creatorcontrib>Gupta, S.</creatorcontrib><creatorcontrib>Morandi, A.</creatorcontrib><creatorcontrib>Mittwede, M.</creatorcontrib><creatorcontrib>Stapelfeldt, E.</creatorcontrib><creatorcontrib>Spoo, M.</creatorcontrib><creatorcontrib>Icke, K.</creatorcontrib><creatorcontrib>Michalsen, A.</creatorcontrib><creatorcontrib>Witt, C.M.</creatorcontrib><title>Effectiveness of an Ayurveda treatment approach in knee osteoarthritis – a randomized controlled trial</title><title>Osteoarthritis and cartilage</title><addtitle>Osteoarthritis Cartilage</addtitle><description>Ayurveda is commonly used in South Asia to treat knee osteoarthritis (OA). We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional conservative care in patients with knee OA.
According to American College of Rheumatology (ACR) criteria knee OA patients were included in a multicenter randomized, controlled, open-label trial and treated in 2 hospital clinics and 2 private outpatient clinics in Germany. Participants received either a multi-modal Ayurvedic treatment or multi-modal conventional care with 15 treatments over 12 weeks respectively. Primary outcome was the change on the Western Ontario and McMaster University Osteoarthritis (WOMAC) Index after 12 weeks. Secondary outcomes included WOMAC subscales; the pain disability index and a pain experience scale, numeric rating scales for pain and sleep quality, quality-of-life and mood, rescue medication use, and safety issues.
One hundred fifty-one participants (Ayurveda n = 77, conventional care n = 74) were included. Changes of the WOMAC Index from baseline to 12 weeks were more pronounced in the Ayurveda group (mean difference 61.0 [95%CI: 52.4;69.6]) than in the conventional group (32.0 [95%CI: 21.4;42.6]) resulting in a significant between-group difference (p < 0.001) and a clinically relevant effect size (Cohen's d 0.68 [95% CI:0.35;1.01]). Similar trends were observed for all secondary outcomes at week 12. Effects were sustained at follow-ups after 6 and 12 months.
Results suggest that Ayurvedic treatment is beneficial in reducing knee OA symptoms. Further studies should be conducted to confirm the magnitude of the effect and to clarify the role of different treatment components and non-specific effects.
at clinicaltrials.gov (NCT01225133; initial release 10/06/2010).</description><subject>Ayurveda</subject><subject>Complementary medicine</subject><subject>Integrative medicine</subject><subject>Knee osteoarthritis</subject><issn>1063-4584</issn><issn>1522-9653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp90MFu1DAQBmALFdF24QU4IB97STpjJ2kicamqApUqcYGz5ThjrZfEXmzvSu2p79A35EnwagvHnjyHf36NP8Y-ItQI2F1u6k0wuhaAfQ1YgxBv2Bm2QlRD18qTMkMnq6btm1N2ntIGACQivGOnYmhEB9CdsfWttWSy25OnlHiwXHt-_bCLe5o0z5F0XshnrrfbGLRZc-f5L0_EQ8oUdMzr6LJL_M_TM9c8aj-FxT3SxE3wOYZ5LmOOTs_v2Vur50QfXt4V-_nl9sfNt-r--9e7m-v7yjQAuZKynfTQAI32yhg79p3AhtoRzdg32BiLFgZpO2kIJzkg9VYgDFa2pm9RgFyxi2Nvuff3jlJWi0uG5ll7CrukBEBhuTrQrJg4Rk0MKUWyahvdouODQlAHYbVRB2F1EFaAqgiXpU8v_btxoen_yj_SEvh8DFD55d5RVMk48oYmF4u0moJ7rf8vEWmOow</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Kessler, C.S.</creator><creator>Dhiman, K.S.</creator><creator>Kumar, A.</creator><creator>Ostermann, T.</creator><creator>Gupta, S.</creator><creator>Morandi, A.</creator><creator>Mittwede, M.</creator><creator>Stapelfeldt, E.</creator><creator>Spoo, M.</creator><creator>Icke, K.</creator><creator>Michalsen, A.</creator><creator>Witt, C.M.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Effectiveness of an Ayurveda treatment approach in knee osteoarthritis – a randomized controlled trial</title><author>Kessler, C.S. ; Dhiman, K.S. ; Kumar, A. ; Ostermann, T. ; Gupta, S. ; Morandi, A. ; Mittwede, M. ; Stapelfeldt, E. ; Spoo, M. ; Icke, K. ; Michalsen, A. ; Witt, C.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-335da940ebf7ccfb86214e5b1cb8414cf1f093f63ce1d391e8f2109f35c851203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ayurveda</topic><topic>Complementary medicine</topic><topic>Integrative medicine</topic><topic>Knee osteoarthritis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kessler, C.S.</creatorcontrib><creatorcontrib>Dhiman, K.S.</creatorcontrib><creatorcontrib>Kumar, A.</creatorcontrib><creatorcontrib>Ostermann, T.</creatorcontrib><creatorcontrib>Gupta, S.</creatorcontrib><creatorcontrib>Morandi, A.</creatorcontrib><creatorcontrib>Mittwede, M.</creatorcontrib><creatorcontrib>Stapelfeldt, E.</creatorcontrib><creatorcontrib>Spoo, M.</creatorcontrib><creatorcontrib>Icke, K.</creatorcontrib><creatorcontrib>Michalsen, A.</creatorcontrib><creatorcontrib>Witt, C.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoarthritis and cartilage</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kessler, C.S.</au><au>Dhiman, K.S.</au><au>Kumar, A.</au><au>Ostermann, T.</au><au>Gupta, S.</au><au>Morandi, A.</au><au>Mittwede, M.</au><au>Stapelfeldt, E.</au><au>Spoo, M.</au><au>Icke, K.</au><au>Michalsen, A.</au><au>Witt, C.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of an Ayurveda treatment approach in knee osteoarthritis – a randomized controlled trial</atitle><jtitle>Osteoarthritis and cartilage</jtitle><addtitle>Osteoarthritis Cartilage</addtitle><date>2018-05</date><risdate>2018</risdate><volume>26</volume><issue>5</issue><spage>620</spage><epage>630</epage><pages>620-630</pages><issn>1063-4584</issn><eissn>1522-9653</eissn><abstract>Ayurveda is commonly used in South Asia to treat knee osteoarthritis (OA). We aimed to evaluate the effectiveness of Ayurvedic treatment compared to conventional conservative care in patients with knee OA.
According to American College of Rheumatology (ACR) criteria knee OA patients were included in a multicenter randomized, controlled, open-label trial and treated in 2 hospital clinics and 2 private outpatient clinics in Germany. Participants received either a multi-modal Ayurvedic treatment or multi-modal conventional care with 15 treatments over 12 weeks respectively. Primary outcome was the change on the Western Ontario and McMaster University Osteoarthritis (WOMAC) Index after 12 weeks. Secondary outcomes included WOMAC subscales; the pain disability index and a pain experience scale, numeric rating scales for pain and sleep quality, quality-of-life and mood, rescue medication use, and safety issues.
One hundred fifty-one participants (Ayurveda n = 77, conventional care n = 74) were included. Changes of the WOMAC Index from baseline to 12 weeks were more pronounced in the Ayurveda group (mean difference 61.0 [95%CI: 52.4;69.6]) than in the conventional group (32.0 [95%CI: 21.4;42.6]) resulting in a significant between-group difference (p < 0.001) and a clinically relevant effect size (Cohen's d 0.68 [95% CI:0.35;1.01]). Similar trends were observed for all secondary outcomes at week 12. Effects were sustained at follow-ups after 6 and 12 months.
Results suggest that Ayurvedic treatment is beneficial in reducing knee OA symptoms. Further studies should be conducted to confirm the magnitude of the effect and to clarify the role of different treatment components and non-specific effects.
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| source | Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Ayurveda Complementary medicine Integrative medicine Knee osteoarthritis |
| title | Effectiveness of an Ayurveda treatment approach in knee osteoarthritis – a randomized controlled trial |
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