Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery
Objectives Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2018-04, Vol.70 (4), p.450-474 |
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| creator | Thabet, Amany A. Youssef, Fadia S. El‐Shazly, Mohamed Singab, Abdel Nasser B. |
| description | Objectives
Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal and economical purposes. This review sheds light on the medicinal values and chemical composition of various species of these two genera.
Key findings
Sterculia and Brachychiton species were used traditionally for the treatment of gastrointestinal disorders, microbial infection, skin diseases, inflammation and many other conditions. The seeds of various species were roasted and eaten by many traditional tribes. Plants from the two genera revealed their anti‐inflammatory, antioxidant, antimicrobial, antidiabetic, antiulcer, insecticidal and analgesic activity. These activities may be attributed to the presence of a wide range of secondary metabolites as flavonoids, phenolic acids, coumarins, terpenoids particularly sesquiterpenes and triterpenes in addition to sterols and fatty acids. Moreover, the gummy exudates obtained from some members of these genera played an important role in different pharmaceutical dosage forms and drug‐delivery systems.
Conclusions
More research is recommended on other species of Sterculia and Brachychiton to discover new molecular entities with potential biological and economic values. |
| doi_str_mv | 10.1111/jphp.12876 |
| format | Article |
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Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal and economical purposes. This review sheds light on the medicinal values and chemical composition of various species of these two genera.
Key findings
Sterculia and Brachychiton species were used traditionally for the treatment of gastrointestinal disorders, microbial infection, skin diseases, inflammation and many other conditions. The seeds of various species were roasted and eaten by many traditional tribes. Plants from the two genera revealed their anti‐inflammatory, antioxidant, antimicrobial, antidiabetic, antiulcer, insecticidal and analgesic activity. These activities may be attributed to the presence of a wide range of secondary metabolites as flavonoids, phenolic acids, coumarins, terpenoids particularly sesquiterpenes and triterpenes in addition to sterols and fatty acids. Moreover, the gummy exudates obtained from some members of these genera played an important role in different pharmaceutical dosage forms and drug‐delivery systems.
Conclusions
More research is recommended on other species of Sterculia and Brachychiton to discover new molecular entities with potential biological and economic values.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.12876</identifier><identifier>PMID: 29423957</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject><![CDATA[Analgesics ; Animals ; Antioxidants ; Antiparasitic Agents - administration & dosage ; Antiparasitic Agents - chemistry ; Antiparasitic Agents - isolation & purification ; Brachychiton ; Communicable Diseases - drug therapy ; Diabetes mellitus ; Drug delivery ; Drug Delivery Systems - methods ; Drug Delivery Systems - trends ; ethnobotany ; Ethnopharmacology ; Ethnopharmacology - methods ; Ethnopharmacology - trends ; Exudates ; Exudation ; Fatty acids ; Flavonoids ; Gastrointestinal diseases ; Gastrointestinal Diseases - drug therapy ; gums ; Humans ; Indigenous species ; Inflammation ; Karaya Gum - administration & dosage ; Karaya Gum - chemistry ; Karaya Gum - isolation & purification ; Malvaceae ; Medical treatment ; Metabolites ; Ornamental trees ; Phenolic acids ; Phenols ; Phytochemicals - administration & dosage ; Phytochemicals - chemistry ; Phytochemicals - isolation & purification ; phytochemistry ; Phytotherapy - methods ; Phytotherapy - trends ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Secondary metabolites ; Seeds ; Sesquiterpenes ; Skin diseases ; Sterculia ; Sterols ; Triterpenes]]></subject><ispartof>Journal of pharmacy and pharmacology, 2018-04, Vol.70 (4), p.450-474</ispartof><rights>2018 Royal Pharmaceutical Society</rights><rights>2018 Royal Pharmaceutical Society.</rights><rights>Copyright © 2018 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-cd68d946baaf17fe94d2364e2189093800047acf1a5ddf70ce6110c632499b2a3</citedby><cites>FETCH-LOGICAL-c3576-cd68d946baaf17fe94d2364e2189093800047acf1a5ddf70ce6110c632499b2a3</cites><orcidid>0000-0002-5871-2639</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.12876$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.12876$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29423957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thabet, Amany A.</creatorcontrib><creatorcontrib>Youssef, Fadia S.</creatorcontrib><creatorcontrib>El‐Shazly, Mohamed</creatorcontrib><creatorcontrib>Singab, Abdel Nasser B.</creatorcontrib><title>Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives
Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal and economical purposes. This review sheds light on the medicinal values and chemical composition of various species of these two genera.
Key findings
Sterculia and Brachychiton species were used traditionally for the treatment of gastrointestinal disorders, microbial infection, skin diseases, inflammation and many other conditions. The seeds of various species were roasted and eaten by many traditional tribes. Plants from the two genera revealed their anti‐inflammatory, antioxidant, antimicrobial, antidiabetic, antiulcer, insecticidal and analgesic activity. These activities may be attributed to the presence of a wide range of secondary metabolites as flavonoids, phenolic acids, coumarins, terpenoids particularly sesquiterpenes and triterpenes in addition to sterols and fatty acids. Moreover, the gummy exudates obtained from some members of these genera played an important role in different pharmaceutical dosage forms and drug‐delivery systems.
Conclusions
More research is recommended on other species of Sterculia and Brachychiton to discover new molecular entities with potential biological and economic values.</description><subject>Analgesics</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antiparasitic Agents - administration & dosage</subject><subject>Antiparasitic Agents - chemistry</subject><subject>Antiparasitic Agents - isolation & purification</subject><subject>Brachychiton</subject><subject>Communicable Diseases - drug therapy</subject><subject>Diabetes mellitus</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Delivery Systems - trends</subject><subject>ethnobotany</subject><subject>Ethnopharmacology</subject><subject>Ethnopharmacology - methods</subject><subject>Ethnopharmacology - trends</subject><subject>Exudates</subject><subject>Exudation</subject><subject>Fatty acids</subject><subject>Flavonoids</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>gums</subject><subject>Humans</subject><subject>Indigenous species</subject><subject>Inflammation</subject><subject>Karaya Gum - administration & dosage</subject><subject>Karaya Gum - chemistry</subject><subject>Karaya Gum - isolation & purification</subject><subject>Malvaceae</subject><subject>Medical treatment</subject><subject>Metabolites</subject><subject>Ornamental trees</subject><subject>Phenolic acids</subject><subject>Phenols</subject><subject>Phytochemicals - administration & dosage</subject><subject>Phytochemicals - chemistry</subject><subject>Phytochemicals - isolation & purification</subject><subject>phytochemistry</subject><subject>Phytotherapy - methods</subject><subject>Phytotherapy - trends</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Secondary metabolites</subject><subject>Seeds</subject><subject>Sesquiterpenes</subject><subject>Skin diseases</subject><subject>Sterculia</subject><subject>Sterols</subject><subject>Triterpenes</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EokvhwgMgS1xQ1RTbyToxN6hoS1WJSsA58tqTtVdOnNrOtnknHhJvd-HAoXPxHD59M-MfobeUnNFcHzejGc8oa2r-DC0YqVhR02XzHC0IYawol3V5hF7FuCGE1Jzzl-iIiYqVYlkv0O8fCYKanJVYDhp_CVKZWRmb_PAJS6x8PwYwMES7Bey3ELYW7rEfcDJgA4ZkBj8aGXqpvPPr-RSv7K6xSjosVbJbmyzEUzyaOXlloLcxhflxWFbg4F32dgfdeur7GcPDpGWCiO2AdZjWWIPL48P8Gr3opIvw5vAeo18XX3-eXxU33y-_nX--KVQ-lhdK80aLiq-k7Gjdgag0K3kFjDaCiLLJ_1DVUnVULrXuaqKAU0oUL1klxIrJ8hh92HvH4O8miKnNWytwTg7gp9gyQijhnHKR0ff_oRs_hSFvlylKRYY4y9TJnlLBxxiga8dgexnmlpJ2l2G7y7B9zDDD7w7KadWD_of-DS0DdA_cWwfzE6r2-vbqdi_9A_SvqsI</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Thabet, Amany A.</creator><creator>Youssef, Fadia S.</creator><creator>El‐Shazly, Mohamed</creator><creator>Singab, Abdel Nasser B.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5871-2639</orcidid></search><sort><creationdate>201804</creationdate><title>Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery</title><author>Thabet, Amany A. ; Youssef, Fadia S. ; El‐Shazly, Mohamed ; Singab, Abdel Nasser B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-cd68d946baaf17fe94d2364e2189093800047acf1a5ddf70ce6110c632499b2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analgesics</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antiparasitic Agents - administration & dosage</topic><topic>Antiparasitic Agents - chemistry</topic><topic>Antiparasitic Agents - isolation & purification</topic><topic>Brachychiton</topic><topic>Communicable Diseases - drug therapy</topic><topic>Diabetes mellitus</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Delivery Systems - trends</topic><topic>ethnobotany</topic><topic>Ethnopharmacology</topic><topic>Ethnopharmacology - methods</topic><topic>Ethnopharmacology - trends</topic><topic>Exudates</topic><topic>Exudation</topic><topic>Fatty acids</topic><topic>Flavonoids</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>gums</topic><topic>Humans</topic><topic>Indigenous species</topic><topic>Inflammation</topic><topic>Karaya Gum - administration & dosage</topic><topic>Karaya Gum - chemistry</topic><topic>Karaya Gum - isolation & purification</topic><topic>Malvaceae</topic><topic>Medical treatment</topic><topic>Metabolites</topic><topic>Ornamental trees</topic><topic>Phenolic acids</topic><topic>Phenols</topic><topic>Phytochemicals - administration & dosage</topic><topic>Phytochemicals - chemistry</topic><topic>Phytochemicals - isolation & purification</topic><topic>phytochemistry</topic><topic>Phytotherapy - methods</topic><topic>Phytotherapy - trends</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Secondary metabolites</topic><topic>Seeds</topic><topic>Sesquiterpenes</topic><topic>Skin diseases</topic><topic>Sterculia</topic><topic>Sterols</topic><topic>Triterpenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thabet, Amany A.</creatorcontrib><creatorcontrib>Youssef, Fadia S.</creatorcontrib><creatorcontrib>El‐Shazly, Mohamed</creatorcontrib><creatorcontrib>Singab, Abdel Nasser B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thabet, Amany A.</au><au>Youssef, Fadia S.</au><au>El‐Shazly, Mohamed</au><au>Singab, Abdel Nasser B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>70</volume><issue>4</issue><spage>450</spage><epage>474</epage><pages>450-474</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Objectives
Sterculia and Brachychiton are two related genera (Malvaceae) containing more than 300 species. Most of these species are ornamental trees that are native to Australia and widely cultivated in many countries. Different members of the two genera were used by various cultures for medicinal and economical purposes. This review sheds light on the medicinal values and chemical composition of various species of these two genera.
Key findings
Sterculia and Brachychiton species were used traditionally for the treatment of gastrointestinal disorders, microbial infection, skin diseases, inflammation and many other conditions. The seeds of various species were roasted and eaten by many traditional tribes. Plants from the two genera revealed their anti‐inflammatory, antioxidant, antimicrobial, antidiabetic, antiulcer, insecticidal and analgesic activity. These activities may be attributed to the presence of a wide range of secondary metabolites as flavonoids, phenolic acids, coumarins, terpenoids particularly sesquiterpenes and triterpenes in addition to sterols and fatty acids. Moreover, the gummy exudates obtained from some members of these genera played an important role in different pharmaceutical dosage forms and drug‐delivery systems.
Conclusions
More research is recommended on other species of Sterculia and Brachychiton to discover new molecular entities with potential biological and economic values.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29423957</pmid><doi>10.1111/jphp.12876</doi><tpages>25</tpages><orcidid>https://orcid.org/0000-0002-5871-2639</orcidid></addata></record> |
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| ispartof | Journal of pharmacy and pharmacology, 2018-04, Vol.70 (4), p.450-474 |
| issn | 0022-3573 2042-7158 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Analgesics Animals Antioxidants Antiparasitic Agents - administration & dosage Antiparasitic Agents - chemistry Antiparasitic Agents - isolation & purification Brachychiton Communicable Diseases - drug therapy Diabetes mellitus Drug delivery Drug Delivery Systems - methods Drug Delivery Systems - trends ethnobotany Ethnopharmacology Ethnopharmacology - methods Ethnopharmacology - trends Exudates Exudation Fatty acids Flavonoids Gastrointestinal diseases Gastrointestinal Diseases - drug therapy gums Humans Indigenous species Inflammation Karaya Gum - administration & dosage Karaya Gum - chemistry Karaya Gum - isolation & purification Malvaceae Medical treatment Metabolites Ornamental trees Phenolic acids Phenols Phytochemicals - administration & dosage Phytochemicals - chemistry Phytochemicals - isolation & purification phytochemistry Phytotherapy - methods Phytotherapy - trends Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - isolation & purification Secondary metabolites Seeds Sesquiterpenes Skin diseases Sterculia Sterols Triterpenes |
| title | Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery |
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