Carbazole alkaloids with antiangiogenic activities from Clausena sanki

[Display omitted] •Clausena sanki is not only a condiment, but also a traditional medicinal herb.•Two new compounds and eleven known isolates were obtained from Clausena sanki.•Compounds 1, 2, 6, 8, and 13 (μM) exhibited moderate antiangiogenic activities. Two new carbazole alkaloids 1 and 2, and el...

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Veröffentlicht in:	Bioorganic chemistry 2018-04, Vol.77, p.387-392
Hauptverfasser:	Wei, Rongrui, Ma, Qinge, Li, Tao, Liu, Wenmin, Sang, Zhipei, Li, Mingbo, Liu, Saimei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals Antiangiogenic activity Carbazole alkaloid Carbazoles - chemistry Carbazoles - isolation & purification Carbazoles - pharmacology Cell Proliferation - drug effects Clausena - chemistry Clausena sanki Dose-Response Relationship, Drug Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Molecular Structure Rutaceae Structure-Activity Relationship Vascular Endothelial Growth Factors - antagonists & inhibitors Vascular Endothelial Growth Factors - metabolism Zebrafish - embryology
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