Synthesis and Characterization of Mono‑, Di‑, and Tri-Poly(ethylene glycol) Chlorin e6 Conjugates for the Photokilling of Human Ovarian Cancer Cells

PEGylated chlorin e6 photosensitizers were synthesized with tri(ethylene glycol) attached at the ester bond(s) for a 1:1 conjugate at the 173-position, a 2:1 conjugate at the 152- and 173-positions, and a 3:1 conjugate at the 131-, 152-, and 173-positions. These chlorin sensitizers were studied for...

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Veröffentlicht in:	Journal of organic chemistry 2012-12, Vol.77 (23), p.10638-10647
Hauptverfasser:	Kimani, Stanley, Ghosh, Goutam, Ghogare, Ashwini, Rudshteyn, Benjamin, Bartusik, Dorota, Hasan, Tayyaba, Greer, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	additives azides Biological and medical sciences Chemistry chlorins ethylene glycol Exact sciences and technology Female free radicals General and physical chemistry Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Humans hydrolysis ions Kinetics and mechanisms lysosomes mannitol Medical sciences neoplasm cells Organic chemistry ovarian neoplasms Ovarian Neoplasms - drug therapy Photochemotherapy - methods Photoradiation therapy and photosensitizing agent photosensitizing agents phototoxicity Polyethylene Glycols - pharmacology Polyethylene Glycols - therapeutic use Porphyrins - pharmacology Porphyrins - therapeutic use Preparations and properties Radiation-Sensitizing Agents - pharmacology Radiation-Sensitizing Agents - therapeutic use Reactivity and mechanisms singlet oxygen Solubility Solutions solvents Treatment with physical agents Treatment. General aspects Tumors water solubility
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