Improvement of lipid production by the oleaginous yeast Rhodosporidium toruloides through UV mutagenesis
Oleaginous yeasts are considered a promising alternative lipid source for biodiesel fuel production. In this study, we attempted to improve the lipid productivity of the oleaginous yeast Rhodosporidium toruloides through UV irradiation mutagenesis and selection based on ethanol and H 2 O 2 tolerance...
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| Veröffentlicht in: | World journal of microbiology & biotechnology 2017-05, Vol.33 (5), p.99-99, Article 99 |
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| creator | Yamada, Ryosuke Kashihara, Tomomi Ogino, Hiroyasu |
| description | Oleaginous yeasts are considered a promising alternative lipid source for biodiesel fuel production. In this study, we attempted to improve the lipid productivity of the oleaginous yeast
Rhodosporidium toruloides
through UV irradiation mutagenesis and selection based on ethanol and H
2
O
2
tolerance or cerulenin, a fatty acid synthetase inhibitor. Glucose consumption, cell growth, and lipid production of mutants were evaluated. The transcription level of genes involved in lipid production was also evaluated in mutants. The ethanol and H
2
O
2
tolerant strain 8766 2-31M and the cerulenin resistant strain 8766 3-11C were generated by UV mutagenesis. The 8766 2-31M mutant showed a higher lipid production rate, and the 8766 3-11C mutant produced a larger amount of lipid and had a higher lipid production rate than the wild type strain. Transcriptional analysis revealed that, similar to the wild type strain, the
ACL1
and
GND1
genes were expressed at significantly low levels, whereas
IDP1
and
ME1
were highly expressed. In conclusion, lipid productivity in the oleaginous yeast
R. toruloides
was successfully improved via UV mutagenesis and selection. The study also identified target genes for improving lipid productivity through gene recombination.
Graphical Abstract |
| doi_str_mv | 10.1007/s11274-017-2269-7 |
| format | Article |
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Rhodosporidium toruloides
through UV irradiation mutagenesis and selection based on ethanol and H
2
O
2
tolerance or cerulenin, a fatty acid synthetase inhibitor. Glucose consumption, cell growth, and lipid production of mutants were evaluated. The transcription level of genes involved in lipid production was also evaluated in mutants. The ethanol and H
2
O
2
tolerant strain 8766 2-31M and the cerulenin resistant strain 8766 3-11C were generated by UV mutagenesis. The 8766 2-31M mutant showed a higher lipid production rate, and the 8766 3-11C mutant produced a larger amount of lipid and had a higher lipid production rate than the wild type strain. Transcriptional analysis revealed that, similar to the wild type strain, the
ACL1
and
GND1
genes were expressed at significantly low levels, whereas
IDP1
and
ME1
were highly expressed. In conclusion, lipid productivity in the oleaginous yeast
R. toruloides
was successfully improved via UV mutagenesis and selection. The study also identified target genes for improving lipid productivity through gene recombination.
Graphical Abstract</description><identifier>ISSN: 0959-3993</identifier><identifier>EISSN: 1573-0972</identifier><identifier>DOI: 10.1007/s11274-017-2269-7</identifier><identifier>PMID: 28429279</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Applied Microbiology ; Basidiomycota - drug effects ; Basidiomycota - genetics ; Basidiomycota - growth & development ; Biochemistry ; biodiesel ; Biodiesel fuels ; Biofuels ; Biomedical and Life Sciences ; Biotechnology ; cell growth ; Cerulenin ; Drug Tolerance ; Environmental Engineering/Biotechnology ; Ethanol ; Ethanol - pharmacology ; Fatty acids ; fatty-acid synthase ; Fuel production ; Fungal Proteins - radiation effects ; gene expression ; Gene Expression Regulation, Fungal - radiation effects ; Genes ; glucose ; Hydrogen peroxide ; Hydrogen Peroxide - pharmacology ; Irradiation ; Life Sciences ; Lipid Metabolism - radiation effects ; Lipids ; Microbiology ; Mutagenesis ; Mutants ; Original Paper ; Productivity ; Recombination ; Rhodosporidium toruloides ; Target recognition ; Transcription ; transcription (genetics) ; Transcriptome ; Ultraviolet radiation ; Yeast ; Yeasts</subject><ispartof>World journal of microbiology & biotechnology, 2017-05, Vol.33 (5), p.99-99, Article 99</ispartof><rights>Springer Science+Business Media Dordrecht 2017</rights><rights>World Journal of Microbiology and Biotechnology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-61c2b8d7231337d7d68ba8f55bbba4aa9a87d6beecbc2ddf7c10f3b1ab181c713</citedby><cites>FETCH-LOGICAL-c508t-61c2b8d7231337d7d68ba8f55bbba4aa9a87d6beecbc2ddf7c10f3b1ab181c713</cites><orcidid>0000-0002-5325-8289</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11274-017-2269-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11274-017-2269-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28429279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Ryosuke</creatorcontrib><creatorcontrib>Kashihara, Tomomi</creatorcontrib><creatorcontrib>Ogino, Hiroyasu</creatorcontrib><title>Improvement of lipid production by the oleaginous yeast Rhodosporidium toruloides through UV mutagenesis</title><title>World journal of microbiology & biotechnology</title><addtitle>World J Microbiol Biotechnol</addtitle><addtitle>World J Microbiol Biotechnol</addtitle><description>Oleaginous yeasts are considered a promising alternative lipid source for biodiesel fuel production. In this study, we attempted to improve the lipid productivity of the oleaginous yeast
Rhodosporidium toruloides
through UV irradiation mutagenesis and selection based on ethanol and H
2
O
2
tolerance or cerulenin, a fatty acid synthetase inhibitor. Glucose consumption, cell growth, and lipid production of mutants were evaluated. The transcription level of genes involved in lipid production was also evaluated in mutants. The ethanol and H
2
O
2
tolerant strain 8766 2-31M and the cerulenin resistant strain 8766 3-11C were generated by UV mutagenesis. The 8766 2-31M mutant showed a higher lipid production rate, and the 8766 3-11C mutant produced a larger amount of lipid and had a higher lipid production rate than the wild type strain. Transcriptional analysis revealed that, similar to the wild type strain, the
ACL1
and
GND1
genes were expressed at significantly low levels, whereas
IDP1
and
ME1
were highly expressed. In conclusion, lipid productivity in the oleaginous yeast
R. toruloides
was successfully improved via UV mutagenesis and selection. The study also identified target genes for improving lipid productivity through gene recombination.
Graphical Abstract</description><subject>Applied Microbiology</subject><subject>Basidiomycota - drug effects</subject><subject>Basidiomycota - genetics</subject><subject>Basidiomycota - growth & development</subject><subject>Biochemistry</subject><subject>biodiesel</subject><subject>Biodiesel fuels</subject><subject>Biofuels</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>cell growth</subject><subject>Cerulenin</subject><subject>Drug Tolerance</subject><subject>Environmental Engineering/Biotechnology</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Fatty acids</subject><subject>fatty-acid synthase</subject><subject>Fuel production</subject><subject>Fungal Proteins - radiation effects</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Fungal - radiation effects</subject><subject>Genes</subject><subject>glucose</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Irradiation</subject><subject>Life Sciences</subject><subject>Lipid Metabolism - radiation effects</subject><subject>Lipids</subject><subject>Microbiology</subject><subject>Mutagenesis</subject><subject>Mutants</subject><subject>Original Paper</subject><subject>Productivity</subject><subject>Recombination</subject><subject>Rhodosporidium toruloides</subject><subject>Target recognition</subject><subject>Transcription</subject><subject>transcription (genetics)</subject><subject>Transcriptome</subject><subject>Ultraviolet radiation</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>0959-3993</issn><issn>1573-0972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtrGzEUhUVpaZy0P6CbIuimm2l1JY8lLUvoIxAIhCRboccdW2Fm5EqjgP99ZZyWUuhKcPWdcx-HkHfAPgFj8nMB4HLdMZAd5xvdyRdkBb0UHdOSvyQrpnvdCa3FGTkv5ZGxptLiNTnjas01l3pFdlfTPqcnnHBeaBroGPcx0FYK1S8xzdQd6LJDmka02zinWugBbVno7S6FVPYpxxDrRJeU65hiwNLwnOp2R-8f6FQXu8UZSyxvyKvBjgXfPr8X5P7b17vLH931zferyy_Xne-ZWroNeO5UkFyAEDLIsFHOqqHvnXN2ba22qtUconeehzBID2wQDqwDBV6CuCAfT75th58Vy2KmWDyOo52xTW84Y6wXPSje0A__oI-p5rlNZ0Dp47V6faTgRPmcSsk4mH2Ok80HA8wcYzCnGEyLwRxjMLJp3j87Vzdh-KP4ffcG8BNQ2te8xfxX6_-6_gKtmZUx</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Yamada, 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Academic</collection><jtitle>World journal of microbiology & biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Ryosuke</au><au>Kashihara, Tomomi</au><au>Ogino, Hiroyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of lipid production by the oleaginous yeast Rhodosporidium toruloides through UV mutagenesis</atitle><jtitle>World journal of microbiology & biotechnology</jtitle><stitle>World J Microbiol Biotechnol</stitle><addtitle>World J Microbiol Biotechnol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>33</volume><issue>5</issue><spage>99</spage><epage>99</epage><pages>99-99</pages><artnum>99</artnum><issn>0959-3993</issn><eissn>1573-0972</eissn><abstract>Oleaginous yeasts are considered a promising alternative lipid source for biodiesel fuel production. In this study, we attempted to improve the lipid productivity of the oleaginous yeast
Rhodosporidium toruloides
through UV irradiation mutagenesis and selection based on ethanol and H
2
O
2
tolerance or cerulenin, a fatty acid synthetase inhibitor. Glucose consumption, cell growth, and lipid production of mutants were evaluated. The transcription level of genes involved in lipid production was also evaluated in mutants. The ethanol and H
2
O
2
tolerant strain 8766 2-31M and the cerulenin resistant strain 8766 3-11C were generated by UV mutagenesis. The 8766 2-31M mutant showed a higher lipid production rate, and the 8766 3-11C mutant produced a larger amount of lipid and had a higher lipid production rate than the wild type strain. Transcriptional analysis revealed that, similar to the wild type strain, the
ACL1
and
GND1
genes were expressed at significantly low levels, whereas
IDP1
and
ME1
were highly expressed. In conclusion, lipid productivity in the oleaginous yeast
R. toruloides
was successfully improved via UV mutagenesis and selection. The study also identified target genes for improving lipid productivity through gene recombination.
Graphical Abstract</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>28429279</pmid><doi>10.1007/s11274-017-2269-7</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5325-8289</orcidid></addata></record> |
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| identifier | ISSN: 0959-3993 |
| ispartof | World journal of microbiology & biotechnology, 2017-05, Vol.33 (5), p.99-99, Article 99 |
| issn | 0959-3993 1573-0972 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Applied Microbiology Basidiomycota - drug effects Basidiomycota - genetics Basidiomycota - growth & development Biochemistry biodiesel Biodiesel fuels Biofuels Biomedical and Life Sciences Biotechnology cell growth Cerulenin Drug Tolerance Environmental Engineering/Biotechnology Ethanol Ethanol - pharmacology Fatty acids fatty-acid synthase Fuel production Fungal Proteins - radiation effects gene expression Gene Expression Regulation, Fungal - radiation effects Genes glucose Hydrogen peroxide Hydrogen Peroxide - pharmacology Irradiation Life Sciences Lipid Metabolism - radiation effects Lipids Microbiology Mutagenesis Mutants Original Paper Productivity Recombination Rhodosporidium toruloides Target recognition Transcription transcription (genetics) Transcriptome Ultraviolet radiation Yeast Yeasts |
| title | Improvement of lipid production by the oleaginous yeast Rhodosporidium toruloides through UV mutagenesis |
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