Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve
Significant progress has been made for tissue imaging of proteins using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). These advancements now facilitate mapping of a wide range of proteins, peptides, and post-translational modifications in a wide variety of tissue...
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| Veröffentlicht in: | Biochimica et biophysica acta 2017-07, Vol.1865 (7), p.927-935 |
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| container_end_page | 935 |
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| container_title | Biochimica et biophysica acta |
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| creator | Angel, Peggi M. Baldwin, H. Scott Gottlieb Sen, Danielle Su, Yan Ru Mayer, John E. Bichell, David Drake, Richard R. |
| description | Significant progress has been made for tissue imaging of proteins using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). These advancements now facilitate mapping of a wide range of proteins, peptides, and post-translational modifications in a wide variety of tissues; however, the use of MALDI IMS to detect proteins from cardiac tissue is limited. This review discusses the most recent advances in protein imaging and demonstrates application to cardiac tissue, including the heart valve. Protein imaging by MALDI IMS allows multiplexed histological mapping of proteins and protein components that are inaccessible by antibodies and should be considered an important tool for basic and clinical cardiovascular research.
•Protein imaging of cardiac tissue is underrepresented in MALDI IMS studies.•We discuss and demonstrate current MALDI IMS approaches that may be used to detail proteins from cardiac tissue.•MALDI IMS has the potential to become an defining tool for proteomic studies in cardiovascular research. |
| doi_str_mv | 10.1016/j.bbapap.2017.03.009 |
| format | Article |
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•Protein imaging of cardiac tissue is underrepresented in MALDI IMS studies.•We discuss and demonstrate current MALDI IMS approaches that may be used to detail proteins from cardiac tissue.•MALDI IMS has the potential to become an defining tool for proteomic studies in cardiovascular research.</description><subject>antibodies</subject><subject>Cardiac</subject><subject>Cardiovascular</subject><subject>desorption</subject><subject>Extracellular matrix</subject><subject>Heart Valves - metabolism</subject><subject>Humans</subject><subject>image analysis</subject><subject>Imaging mass spectrometry</subject><subject>ionization</subject><subject>mass spectrometry</subject><subject>Protein imaging</subject><subject>Protein Processing, Post-Translational - physiology</subject><subject>proteins</subject><subject>Proteins - metabolism</subject><subject>Semilunar valve</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</subject><subject>tissues</subject><issn>1570-9639</issn><issn>0006-3002</issn><issn>1878-1454</issn><issn>1878-2434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiNERUvhHyDkIweSjh07di5Iq5aPSou4wNly7MmuV_nCTiL13-NlS4FLexrLft_xvPNk2RsKBQVaXR2KpjGTmQoGVBZQFgD1s-yCKqlyygV_ns5CQl5XZX2evYzxAMBASvEiO2eq5LQCepG5jVvNYDESP5Cvm-3NLfG92flhR3oTI4kT2jmMPc7hjowtmcI4ox9-y60JzhtLZh_jgu_Tle0Wd7TOeyR7NGEmq-lWfJWdtaaL-Pq-XmY_Pn38fv0l3377fHu92eZWVGzOlWxaqLgRDjin4GjLrWBQSWOZ4DU2laQo0FBHRekU40qCLIXgijLOWFleZh9Ofael6dFZHOZgOj2FFCnc6dF4_f_L4Pd6N65aCCaZFKnBu_sGYfy5YJx176PFrjMDjkvUDADS4lJ5UkpVmqpSqqZJyk9SG8YYA7YPE1HQR5b6oE8s9ZGlhlInlsn29t80D6Y_8P7GxbTT1WPQ0XpMMJ0PiZp2o3_8h1_7ALE5</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Angel, Peggi M.</creator><creator>Baldwin, H. Scott</creator><creator>Gottlieb Sen, Danielle</creator><creator>Su, Yan Ru</creator><creator>Mayer, John E.</creator><creator>Bichell, David</creator><creator>Drake, Richard R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20170701</creationdate><title>Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve</title><author>Angel, Peggi M. ; Baldwin, H. Scott ; Gottlieb Sen, Danielle ; Su, Yan Ru ; Mayer, John E. ; Bichell, David ; Drake, Richard R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-87bf064a5d04410d1f4c52067ac2549eb671e5ea1d153d8248707355481242233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>antibodies</topic><topic>Cardiac</topic><topic>Cardiovascular</topic><topic>desorption</topic><topic>Extracellular matrix</topic><topic>Heart Valves - metabolism</topic><topic>Humans</topic><topic>image analysis</topic><topic>Imaging mass spectrometry</topic><topic>ionization</topic><topic>mass spectrometry</topic><topic>Protein imaging</topic><topic>Protein Processing, Post-Translational - physiology</topic><topic>proteins</topic><topic>Proteins - metabolism</topic><topic>Semilunar valve</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods</topic><topic>tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Angel, Peggi M.</creatorcontrib><creatorcontrib>Baldwin, H. Scott</creatorcontrib><creatorcontrib>Gottlieb Sen, Danielle</creatorcontrib><creatorcontrib>Su, Yan Ru</creatorcontrib><creatorcontrib>Mayer, John E.</creatorcontrib><creatorcontrib>Bichell, David</creatorcontrib><creatorcontrib>Drake, Richard R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochimica et biophysica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Angel, Peggi M.</au><au>Baldwin, H. Scott</au><au>Gottlieb Sen, Danielle</au><au>Su, Yan Ru</au><au>Mayer, John E.</au><au>Bichell, David</au><au>Drake, Richard R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve</atitle><jtitle>Biochimica et biophysica acta</jtitle><addtitle>Biochim Biophys Acta Proteins Proteom</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>1865</volume><issue>7</issue><spage>927</spage><epage>935</epage><pages>927-935</pages><issn>1570-9639</issn><issn>0006-3002</issn><eissn>1878-1454</eissn><eissn>1878-2434</eissn><abstract>Significant progress has been made for tissue imaging of proteins using matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). These advancements now facilitate mapping of a wide range of proteins, peptides, and post-translational modifications in a wide variety of tissues; however, the use of MALDI IMS to detect proteins from cardiac tissue is limited. This review discusses the most recent advances in protein imaging and demonstrates application to cardiac tissue, including the heart valve. Protein imaging by MALDI IMS allows multiplexed histological mapping of proteins and protein components that are inaccessible by antibodies and should be considered an important tool for basic and clinical cardiovascular research.
•Protein imaging of cardiac tissue is underrepresented in MALDI IMS studies.•We discuss and demonstrate current MALDI IMS approaches that may be used to detail proteins from cardiac tissue.•MALDI IMS has the potential to become an defining tool for proteomic studies in cardiovascular research.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>28341601</pmid><doi>10.1016/j.bbapap.2017.03.009</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | antibodies Cardiac Cardiovascular desorption Extracellular matrix Heart Valves - metabolism Humans image analysis Imaging mass spectrometry ionization mass spectrometry Protein imaging Protein Processing, Post-Translational - physiology proteins Proteins - metabolism Semilunar valve Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods tissues |
| title | Advances in MALDI imaging mass spectrometry of proteins in cardiac tissue, including the heart valve |
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