Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution

Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exorne in 81 diverse cell types. We found that -15%...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-12, Vol.342 (6164), p.1367-1372
Hauptverfasser:	Stergachis, Andrew B., Haugen, Eric, Shafer, Anthony, Fu, Wenqing, LeProust, M., Akey, Joshua M., Stamatoyannopoulos, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid sequences Amino acids Binding binding sites Cells Coding Codon - genetics Codons Deoxyribonuclease I - chemistry DNA DNA Footprinting Evolution Evolution, Molecular Evolutionary Evolutionary biology Exome Exons Genes Genetic code Genome, Human Genomes Genomics Human Humans Nucleic acids Open reading frames P values Polymorphism, Single Nucleotide Proteins transcription (genetics) transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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