In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

Prenatal exposures of a mother can affect the health of her offspring, but how? Radford et al. found that the male progeny of undernourished pregnant mice had altered DNA chemistry in their sperm. In addition, the offspring displayed compromised metabolic health. The specific affected genes not only...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-08, Vol.345 (6198), p.785-785
Hauptverfasser:	Radford, Elizabeth J., Ito, Mitsuteru, Shi, Hui, Corish, Jennifer A., Yamazawa, Kazuki, Isganaitis, Elvira, Seisenberger, Stefanie, Hore, Timothy A., Reik, Wolf, Erkek, Serap, Peters, Antoine H. F. M., Patti, Mary-Elizabeth, Ferguson-Smith, Anne C.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Body Weight Coding Deoxyribonucleic acid DNA DNA methylation DNA packaging Environmental Influences Genes Health Individualized Instruction Males malnutrition Metabolism Methylation mice nucleosomes Organic Chemistry Packaging Pregnancy Progeny Programming protamines RESEARCH ARTICLE SUMMARY spermatozoa
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