Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice

Bile acid synthesis is the major pathway for catabolism of cholesterol. Cholesterol 7α-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway in the liver and plays an important role in regulating lipid, glucose and energy metabolism. Transgenic mice overexpressing CY...

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Veröffentlicht in:	Biochimica et biophysica acta 2015-01, Vol.1851 (1), p.19-29
Hauptverfasser:	Qi, Yunpeng, Jiang, Changtao, Cheng, Jie, Krausz, Kristopher W., Li, Tiangang, Ferrell, Jessica M., Gonzalez, Frank J., Chiang, John Y.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists bile acid metabolism Bile Acids and Salts - genetics Bile Acids and Salts - metabolism biochemical pathways blood serum ceramides cholesterol Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism cholesterol 7alpha-monooxygenase CYP7A1 diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diet, High-Fat - methods energy metabolism farnesoid X receptor (FXR) fatty liver Female gene overexpression glucose Glucose - genetics Glucose - metabolism high fat diet Homeostasis Insulin Resistance intestines Intestines - metabolism ionization lipid metabolism Lipid Metabolism - physiology lipidomics liver Liver - metabolism lysophosphatidylcholine Male mass spectrometry metabolites Metabolome - genetics metabolomics Metabolomics - methods Mice Mice, Inbred C57BL Mice, Transgenic multivariate analysis obesity Obesity - genetics Obesity - metabolism Rats Signal Transduction sphingomyelins tauro-β-muricholic acid taurocholic acid Taurocholic Acid - analogs & derivatives Taurocholic Acid - genetics Taurocholic Acid - metabolism transgenic animals
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