Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T-cell-intrinsic expres...

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Veröffentlicht in:	Cell 2016-08, Vol.166 (5), p.1117-1131.e14
Hauptverfasser:	Clever, David, Roychoudhuri, Rahul, Constantinides, Michael G., Askenase, Michael H., Sukumar, Madhusudhanan, Klebanoff, Christopher A., Eil, Robert L., Hickman, Heather D., Yu, Zhiya, Pan, Jenny H., Palmer, Douglas C., Phan, Anthony T., Goulding, John, Gattinoni, Luca, Goldrath, Ananda W., Belkaid, Yasmine, Restifo, Nicholas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals antigens CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology Glycolysis - immunology immune response immunotherapy Interferon-gamma - immunology Lung - immunology Lung - pathology Lung Neoplasms - immunology Lung Neoplasms - secondary Lung Neoplasms - therapy Lymphocyte Activation metastasis Mice Mice, Knockout neoplasm cells Neoplasm Metastasis neoplasms Neuropilin-1 - metabolism oxygen Oxygen - metabolism Prolyl Hydroxylases - genetics Prolyl Hydroxylases - metabolism proteins T-Lymphocytes, Regulatory - enzymology T-Lymphocytes, Regulatory - immunology Th1 Cells - enzymology Th1 Cells - immunology
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