Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription
•SET/TAF-Iβ inhibits FoxO1 acetylation.•SET/TAF-Iβ interacts with FoxO1 in INHAT domain dependent manner.•Recruitment of FoxO1 on p21 promoter is increased by SET/TAF-Iβ.•SET/TAF-Iβ induces p21 transcription and apoptosis under oxidative stress. Post-translational modification of forkhead family tra...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2014-08, Vol.588 (17), p.2867-2873 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2873 |
|---|---|
| container_issue | 17 |
| container_start_page | 2867 |
| container_title | FEBS letters |
| container_volume | 588 |
| creator | Chae, Yun-Cheol Kim, Kee-Beom Kang, Joo-Young Kim, Se-Ryeon Jung, Hyeon-Soo Seo, Sang-Beom |
| description | •SET/TAF-Iβ inhibits FoxO1 acetylation.•SET/TAF-Iβ interacts with FoxO1 in INHAT domain dependent manner.•Recruitment of FoxO1 on p21 promoter is increased by SET/TAF-Iβ.•SET/TAF-Iβ induces p21 transcription and apoptosis under oxidative stress.
Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.
FoxO1physically interacts with SET/TAF-Iβ by pull down (1, 2)
FoxO1physically interacts with SET/TAF-Iβ by anti tag coimmunoprecipitation (View interaction)
SET/TAF-Iβphysically interacts with FoxO1 by anti bait coip (1, 2) |
| doi_str_mv | 10.1016/j.febslet.2014.06.053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2000219060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S001457931400516X</els_id><sourcerecordid>1635013529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c496X-f7da828da8ece1e5aa6429e3c4cfb4129e2bebc2415579883ebb06dd0096c3b33</originalsourceid><addsrcrecordid>eNqNkc2O0zAUhS0EYsrAI4C8ZJOM_-usUBm1tNKIWUxBs7Ns50a4SpNiJ0BfiwfhmXBoYVsWtq_tc4599SH0mpKSEqpudmUDLrUwlIxQURJVEsmfoBnVc15wofRTNCP5ppDzil-hFyntSN5rWj1HV0xUmucxQ5833ZfgwhD6DvcNXvU_7im2HoZja_8cuiPefFwvtjiNbuzCgB-W25vtYlVsfv3EoatHDwkfGMVDtF3yMRwm20v0rLFtglfn9Rp9Wi23t-vi7v7D5nZxV3hRqceimddWM50n8EBBWqsEq4B74RsnaC6ZA-eZoDK3oTUH54iqa0Iq5bnj_Bq9PeUeYv91hDSYfUge2tZ20I_JsNwzoxVR5KKUKi4J5ZJVl6VSCqHYXIsslSepj31KERpziGFv49FQYiZQZmfOoMwEyhBlMqjse3N-YnR7qP-5_pLJgvVJ8D20cPy_VLNavmcPE_UJOhWESKoec9S7UxRkEt8CRJN8gM5DHSL4wdR9uPDb30qwuyU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1554462784</pqid></control><display><type>article</type><title>Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Chae, Yun-Cheol ; Kim, Kee-Beom ; Kang, Joo-Young ; Kim, Se-Ryeon ; Jung, Hyeon-Soo ; Seo, Sang-Beom</creator><creatorcontrib>Chae, Yun-Cheol ; Kim, Kee-Beom ; Kang, Joo-Young ; Kim, Se-Ryeon ; Jung, Hyeon-Soo ; Seo, Sang-Beom</creatorcontrib><description>•SET/TAF-Iβ inhibits FoxO1 acetylation.•SET/TAF-Iβ interacts with FoxO1 in INHAT domain dependent manner.•Recruitment of FoxO1 on p21 promoter is increased by SET/TAF-Iβ.•SET/TAF-Iβ induces p21 transcription and apoptosis under oxidative stress.
Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.
FoxO1physically interacts with SET/TAF-Iβ by pull down (1, 2)
FoxO1physically interacts with SET/TAF-Iβ by anti tag coimmunoprecipitation (View interaction)
SET/TAF-Iβphysically interacts with FoxO1 by anti bait coip (1, 2)</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2014.06.053</identifier><identifier>PMID: 24983498</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Acetylation ; Apoptosis ; binding capacity ; Cyclin-Dependent Kinase Inhibitor p21 - genetics ; DNA ; Forkhead Box Protein O1 ; Forkhead Transcription Factors - metabolism ; FoxO1 ; Gene Expression Regulation ; genes ; HCT116 Cells ; HEK293 Cells ; Histone Chaperones - metabolism ; Humans ; Oxidative Stress ; p21 ; post-translational modification ; Protein Subunits - metabolism ; SET/TAF-Iβ ; Transcription ; transcription (genetics) ; transcription factors ; Transcription Factors - metabolism ; Transcription, Genetic</subject><ispartof>FEBS letters, 2014-08, Vol.588 (17), p.2867-2873</ispartof><rights>2014 Federation of European Biochemical Societies</rights><rights>FEBS Letters 588 (2014) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496X-f7da828da8ece1e5aa6429e3c4cfb4129e2bebc2415579883ebb06dd0096c3b33</citedby><cites>FETCH-LOGICAL-c496X-f7da828da8ece1e5aa6429e3c4cfb4129e2bebc2415579883ebb06dd0096c3b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2014.06.053$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001457931400516X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24983498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chae, Yun-Cheol</creatorcontrib><creatorcontrib>Kim, Kee-Beom</creatorcontrib><creatorcontrib>Kang, Joo-Young</creatorcontrib><creatorcontrib>Kim, Se-Ryeon</creatorcontrib><creatorcontrib>Jung, Hyeon-Soo</creatorcontrib><creatorcontrib>Seo, Sang-Beom</creatorcontrib><title>Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>•SET/TAF-Iβ inhibits FoxO1 acetylation.•SET/TAF-Iβ interacts with FoxO1 in INHAT domain dependent manner.•Recruitment of FoxO1 on p21 promoter is increased by SET/TAF-Iβ.•SET/TAF-Iβ induces p21 transcription and apoptosis under oxidative stress.
Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.
FoxO1physically interacts with SET/TAF-Iβ by pull down (1, 2)
FoxO1physically interacts with SET/TAF-Iβ by anti tag coimmunoprecipitation (View interaction)
SET/TAF-Iβphysically interacts with FoxO1 by anti bait coip (1, 2)</description><subject>Acetylation</subject><subject>Apoptosis</subject><subject>binding capacity</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - genetics</subject><subject>DNA</subject><subject>Forkhead Box Protein O1</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>FoxO1</subject><subject>Gene Expression Regulation</subject><subject>genes</subject><subject>HCT116 Cells</subject><subject>HEK293 Cells</subject><subject>Histone Chaperones - metabolism</subject><subject>Humans</subject><subject>Oxidative Stress</subject><subject>p21</subject><subject>post-translational modification</subject><subject>Protein Subunits - metabolism</subject><subject>SET/TAF-Iβ</subject><subject>Transcription</subject><subject>transcription (genetics)</subject><subject>transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EYsrAI4C8ZJOM_-usUBm1tNKIWUxBs7Ns50a4SpNiJ0BfiwfhmXBoYVsWtq_tc4599SH0mpKSEqpudmUDLrUwlIxQURJVEsmfoBnVc15wofRTNCP5ppDzil-hFyntSN5rWj1HV0xUmucxQ5833ZfgwhD6DvcNXvU_7im2HoZja_8cuiPefFwvtjiNbuzCgB-W25vtYlVsfv3EoatHDwkfGMVDtF3yMRwm20v0rLFtglfn9Rp9Wi23t-vi7v7D5nZxV3hRqceimddWM50n8EBBWqsEq4B74RsnaC6ZA-eZoDK3oTUH54iqa0Iq5bnj_Bq9PeUeYv91hDSYfUge2tZ20I_JsNwzoxVR5KKUKi4J5ZJVl6VSCqHYXIsslSepj31KERpziGFv49FQYiZQZmfOoMwEyhBlMqjse3N-YnR7qP-5_pLJgvVJ8D20cPy_VLNavmcPE_UJOhWESKoec9S7UxRkEt8CRJN8gM5DHSL4wdR9uPDb30qwuyU</recordid><startdate>20140825</startdate><enddate>20140825</enddate><creator>Chae, Yun-Cheol</creator><creator>Kim, Kee-Beom</creator><creator>Kang, Joo-Young</creator><creator>Kim, Se-Ryeon</creator><creator>Jung, Hyeon-Soo</creator><creator>Seo, Sang-Beom</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20140825</creationdate><title>Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription</title><author>Chae, Yun-Cheol ; Kim, Kee-Beom ; Kang, Joo-Young ; Kim, Se-Ryeon ; Jung, Hyeon-Soo ; Seo, Sang-Beom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496X-f7da828da8ece1e5aa6429e3c4cfb4129e2bebc2415579883ebb06dd0096c3b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetylation</topic><topic>Apoptosis</topic><topic>binding capacity</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - genetics</topic><topic>DNA</topic><topic>Forkhead Box Protein O1</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>FoxO1</topic><topic>Gene Expression Regulation</topic><topic>genes</topic><topic>HCT116 Cells</topic><topic>HEK293 Cells</topic><topic>Histone Chaperones - metabolism</topic><topic>Humans</topic><topic>Oxidative Stress</topic><topic>p21</topic><topic>post-translational modification</topic><topic>Protein Subunits - metabolism</topic><topic>SET/TAF-Iβ</topic><topic>Transcription</topic><topic>transcription (genetics)</topic><topic>transcription factors</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chae, Yun-Cheol</creatorcontrib><creatorcontrib>Kim, Kee-Beom</creatorcontrib><creatorcontrib>Kang, Joo-Young</creatorcontrib><creatorcontrib>Kim, Se-Ryeon</creatorcontrib><creatorcontrib>Jung, Hyeon-Soo</creatorcontrib><creatorcontrib>Seo, Sang-Beom</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chae, Yun-Cheol</au><au>Kim, Kee-Beom</au><au>Kang, Joo-Young</au><au>Kim, Se-Ryeon</au><au>Jung, Hyeon-Soo</au><au>Seo, Sang-Beom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2014-08-25</date><risdate>2014</risdate><volume>588</volume><issue>17</issue><spage>2867</spage><epage>2873</epage><pages>2867-2873</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>•SET/TAF-Iβ inhibits FoxO1 acetylation.•SET/TAF-Iβ interacts with FoxO1 in INHAT domain dependent manner.•Recruitment of FoxO1 on p21 promoter is increased by SET/TAF-Iβ.•SET/TAF-Iβ induces p21 transcription and apoptosis under oxidative stress.
Post-translational modification of forkhead family transcription factor, FoxO1, is an important regulatory mode for its diverse activities. FoxO1 is acetylated by HAT coactivators and its transcriptional activity is decreased via reduced DNA binding affinity. Here, we report that SET/TAF-Iβ inhibited p300-mediated FoxO1 acetylation in an INHAT domain-dependent manner. SET/TAF-Iβ interacted with FoxO1 and activated transcription of FoxO1 target gene, p21. Moreover, SET/TAF-Iβ inhibited acetylation of FoxO1 and increased p21 transcription induced by oxidative stress. Our results suggest that SET/TAF-Iβ inhibits FoxO1 acetylation and activates its transcriptional activity toward p21.
FoxO1physically interacts with SET/TAF-Iβ by pull down (1, 2)
FoxO1physically interacts with SET/TAF-Iβ by anti tag coimmunoprecipitation (View interaction)
SET/TAF-Iβphysically interacts with FoxO1 by anti bait coip (1, 2)</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>24983498</pmid><doi>10.1016/j.febslet.2014.06.053</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2014-08, Vol.588 (17), p.2867-2873 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2000219060 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetylation Apoptosis binding capacity Cyclin-Dependent Kinase Inhibitor p21 - genetics DNA Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FoxO1 Gene Expression Regulation genes HCT116 Cells HEK293 Cells Histone Chaperones - metabolism Humans Oxidative Stress p21 post-translational modification Protein Subunits - metabolism SET/TAF-Iβ Transcription transcription (genetics) transcription factors Transcription Factors - metabolism Transcription, Genetic |
| title | Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T05%3A56%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20FoxO1%20acetylation%20by%20INHAT%20subunit%20SET/TAF-I%CE%B2%20induces%20p21%20transcription&rft.jtitle=FEBS%20letters&rft.au=Chae,%20Yun-Cheol&rft.date=2014-08-25&rft.volume=588&rft.issue=17&rft.spage=2867&rft.epage=2873&rft.pages=2867-2873&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/j.febslet.2014.06.053&rft_dat=%3Cproquest_cross%3E1635013529%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1554462784&rft_id=info:pmid/24983498&rft_els_id=S001457931400516X&rfr_iscdi=true |