Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

Research in two fronts has enabled the development of therapies that provide significant benefit to cancer patients. One area stems from a detailed knowledge of mutations that activate or inactivate signaling pathways that drive cancer development. This work triggered the development of targeted the...

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Veröffentlicht in:	Cell 2015-04, Vol.161 (2), p.205-214
Hauptverfasser:	Sharma, Padmanee, Allison, James P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carcinogenesis cell-mediated immunity Drug Delivery Systems evolution funding Humans Immunotherapy Mutation neoplasms Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy patients Precision Medicine signal transduction Signal Transduction - drug effects T-lymphocytes T-Lymphocytes - immunology therapeutics
Online-Zugang:	Volltext
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