Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298

Statins are potent inhibitors of cholesterol biosynthesis and are clinically beneficial in preventing cardiovascular diseases, however, the therapeutic utility of these drugs is limited by myotoxicity. Here, we explored the mechanism of statin-mediated activation of ERK5 in the human endothelium wit...

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Veröffentlicht in:	Biochimica et biophysica acta 2015-07, Vol.1850 (7), p.1415-1425
Hauptverfasser:	Chu, Uyen B., Duellman, Tyler, Weaver, Sara J., Tao, Yunting, Yang, Jay
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Animals anticholesteremic agents Benzamides - pharmacology biomarkers biosynthesis Blotting, Western cardiovascular diseases Cell Line Cells, Cultured Cercopithecus aethiops COS Cells Endothelial Cells - drug effects Endothelial Cells - metabolism endothelial nitric oxide synthase Endothelial protection endothelium Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology ERK5 FTI-277 Gene Expression - drug effects genes GGTI-298 human umbilical vein endothelial cells Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism luciferase Methionine - analogs & derivatives Methionine - pharmacology Mice Mitogen-Activated Protein Kinase 7 - genetics Mitogen-Activated Protein Kinase 7 - metabolism Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - metabolism muscular diseases Myopathy myotubes Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Phosphorylation - drug effects Pitavastatin quantitative polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction signal transduction Thrombomodulin - genetics Thrombomodulin - metabolism transcription (genetics) transcriptional activation
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