Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia
The genus Ambrosiella accommodates species of Ceratocystidaceae (Microascales) that are obligate, mutualistic symbionts of ambrosia beetles, but the genus appears to be polyphyletic and more diverse than previously recognized. In addition to Ambrosiella xylebori, Ambrosiella hartigii, Ambrosiella be...
Gespeichert in:
| Veröffentlicht in: | Fungal biology 2015-11, Vol.119 (11), p.1075-1092 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1092 |
|---|---|
| container_issue | 11 |
| container_start_page | 1075 |
| container_title | Fungal biology |
| container_volume | 119 |
| creator | Mayers, Chase G. McNew, Douglas L. Harrington, Thomas C. Roeper, Richard A. Fraedrich, Stephen W. Biedermann, Peter H.W. Castrillo, Louela A. Reed, Sharon E. |
| description | The genus Ambrosiella accommodates species of Ceratocystidaceae (Microascales) that are obligate, mutualistic symbionts of ambrosia beetles, but the genus appears to be polyphyletic and more diverse than previously recognized. In addition to Ambrosiella xylebori, Ambrosiella hartigii, Ambrosiella beaveri, and Ambrosiella roeperi, three new species of Ambrosiella are described from the ambrosia beetle tribe Xyleborini: Ambrosiella nakashimae sp. nov. from Xylosandrus amputatus, Ambrosiella batrae sp. nov. from Anisandrus sayi, and Ambrosiella grosmanniae sp. nov. from Xylosandrus germanus. The genus Meredithiella gen. nov. is created for symbionts of the tribe Corthylini, based on Meredithiella norrisii sp. nov. from Corthylus punctatissimus. The genus Phialophoropsis is resurrected to accommodate associates of the Xyloterini, including Phialophoropsis trypodendri from Trypodendron scabricollis and Phialophoropsis ferruginea comb. nov. from Trypodendron lineatum. Each of the ten named species was distinguished by ITS rDNA barcoding and morphology, and the ITS rDNA sequences of four other putative species were obtained with Ceratocystidaceae-specific primers and template DNA extracted from beetles or galleries. These results support the hypothesis that each ambrosia beetle species with large, complex mycangia carries its own fungal symbiont. Conidiophore morphology and phylogenetic analyses using 18S (SSU) rDNA and TEF1α DNA sequences suggest that these three fungal genera within the Ceratocystidaceae independently adapted to symbiosis with the three respective beetle tribes. In turn, the beetle genera with large, complex mycangia appear to have evolved from other genera in their respective tribes that have smaller, less selective mycangia and are associated with Raffaelea spp. (Ophiostomatales). |
| doi_str_mv | 10.1016/j.funbio.2015.08.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2000153837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1878614615001397</els_id><sourcerecordid>2000153837</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-9f9c5fc21de584271bfb251426b994c49c2d45a25b56d2f79daded6b31656dfe3</originalsourceid><addsrcrecordid>eNqFkUtv3CAQx1HVqImSfIOq4thD1wVsY7hUqlZ9SZFySc6Ix7DLysYusGn2Y_Qbl82mObYcYDTzmwfzR-gtJQ0llH_cNX4fTZgbRmjfENEQwl6hCyoGseKUs9cvdsfP0XXOO1JPS1shhzfonPGOcyHoBfp9t00AeAMRksYh4rIFvK52me0hl-C0BQ1YJ3iKJMgL2BIeAOfDVAeIJePZ19ixSogOFqhXLHgMEfQGnqJ6MmnOQWMDUMbq-xXKFo86beADtvO0jPCIp4PVcRP0FTrzesxw_fxeovuvX-7W31c3t99-rD_frGwnWVlJL23vLaMOetGxgRpvWE87xo2UXWUsc12vWW967pgfpNMOHDct5dXhob1E7091lzT_3EMuagrZwjjqCPM-K1YXRvtWtMN_UTowJlvCZFfR7oTa-uOcwKslhUmng6JEHaVTO3WSTh2lU0SoKl1Ne_fcYW8mcC9Jf4WqwKcTAHUlDwGSyjZAtOBCqoIoN4d_d_gDCOGuuA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1722930294</pqid></control><display><type>article</type><title>Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Mayers, Chase G. ; McNew, Douglas L. ; Harrington, Thomas C. ; Roeper, Richard A. ; Fraedrich, Stephen W. ; Biedermann, Peter H.W. ; Castrillo, Louela A. ; Reed, Sharon E.</creator><creatorcontrib>Mayers, Chase G. ; McNew, Douglas L. ; Harrington, Thomas C. ; Roeper, Richard A. ; Fraedrich, Stephen W. ; Biedermann, Peter H.W. ; Castrillo, Louela A. ; Reed, Sharon E.</creatorcontrib><description>The genus Ambrosiella accommodates species of Ceratocystidaceae (Microascales) that are obligate, mutualistic symbionts of ambrosia beetles, but the genus appears to be polyphyletic and more diverse than previously recognized. In addition to Ambrosiella xylebori, Ambrosiella hartigii, Ambrosiella beaveri, and Ambrosiella roeperi, three new species of Ambrosiella are described from the ambrosia beetle tribe Xyleborini: Ambrosiella nakashimae sp. nov. from Xylosandrus amputatus, Ambrosiella batrae sp. nov. from Anisandrus sayi, and Ambrosiella grosmanniae sp. nov. from Xylosandrus germanus. The genus Meredithiella gen. nov. is created for symbionts of the tribe Corthylini, based on Meredithiella norrisii sp. nov. from Corthylus punctatissimus. The genus Phialophoropsis is resurrected to accommodate associates of the Xyloterini, including Phialophoropsis trypodendri from Trypodendron scabricollis and Phialophoropsis ferruginea comb. nov. from Trypodendron lineatum. Each of the ten named species was distinguished by ITS rDNA barcoding and morphology, and the ITS rDNA sequences of four other putative species were obtained with Ceratocystidaceae-specific primers and template DNA extracted from beetles or galleries. These results support the hypothesis that each ambrosia beetle species with large, complex mycangia carries its own fungal symbiont. Conidiophore morphology and phylogenetic analyses using 18S (SSU) rDNA and TEF1α DNA sequences suggest that these three fungal genera within the Ceratocystidaceae independently adapted to symbiosis with the three respective beetle tribes. In turn, the beetle genera with large, complex mycangia appear to have evolved from other genera in their respective tribes that have smaller, less selective mycangia and are associated with Raffaelea spp. (Ophiostomatales).</description><identifier>ISSN: 1878-6146</identifier><identifier>EISSN: 1878-6162</identifier><identifier>DOI: 10.1016/j.funbio.2015.08.002</identifier><identifier>PMID: 26466881</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Ambrosia - parasitology ; ambrosia beetles ; Ambrosia fungi ; Ambrosiella beaveri ; Animals ; Ascomycota - classification ; Ascomycota - genetics ; Ascomycota - isolation & purification ; Ascomycota - physiology ; barcoding ; Cluster Analysis ; Corthylus ; DNA, Fungal - chemistry ; DNA, Fungal - genetics ; DNA, Ribosomal - chemistry ; DNA, Ribosomal - genetics ; DNA, Ribosomal Spacer - chemistry ; DNA, Ribosomal Spacer - genetics ; fungi ; Genetic Variation ; internal transcribed spacers ; Molecular Sequence Data ; new combination ; new genus ; new species ; Peptide Elongation Factor 1 - genetics ; Phylogeny ; polyphyly ; Raffaelea ; ribosomal DNA ; RNA, Ribosomal, 18S - genetics ; Scolytinae ; Sequence Analysis, DNA ; symbionts ; Symbiosis ; Trypodendron lineatum ; Weevils - microbiology ; Xyleborus ; Xylosandrus</subject><ispartof>Fungal biology, 2015-11, Vol.119 (11), p.1075-1092</ispartof><rights>2015 The British Mycological Society</rights><rights>Copyright © 2015 The British Mycological Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-9f9c5fc21de584271bfb251426b994c49c2d45a25b56d2f79daded6b31656dfe3</citedby><cites>FETCH-LOGICAL-c492t-9f9c5fc21de584271bfb251426b994c49c2d45a25b56d2f79daded6b31656dfe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.funbio.2015.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26466881$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mayers, Chase G.</creatorcontrib><creatorcontrib>McNew, Douglas L.</creatorcontrib><creatorcontrib>Harrington, Thomas C.</creatorcontrib><creatorcontrib>Roeper, Richard A.</creatorcontrib><creatorcontrib>Fraedrich, Stephen W.</creatorcontrib><creatorcontrib>Biedermann, Peter H.W.</creatorcontrib><creatorcontrib>Castrillo, Louela A.</creatorcontrib><creatorcontrib>Reed, Sharon E.</creatorcontrib><title>Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia</title><title>Fungal biology</title><addtitle>Fungal Biol</addtitle><description>The genus Ambrosiella accommodates species of Ceratocystidaceae (Microascales) that are obligate, mutualistic symbionts of ambrosia beetles, but the genus appears to be polyphyletic and more diverse than previously recognized. In addition to Ambrosiella xylebori, Ambrosiella hartigii, Ambrosiella beaveri, and Ambrosiella roeperi, three new species of Ambrosiella are described from the ambrosia beetle tribe Xyleborini: Ambrosiella nakashimae sp. nov. from Xylosandrus amputatus, Ambrosiella batrae sp. nov. from Anisandrus sayi, and Ambrosiella grosmanniae sp. nov. from Xylosandrus germanus. The genus Meredithiella gen. nov. is created for symbionts of the tribe Corthylini, based on Meredithiella norrisii sp. nov. from Corthylus punctatissimus. The genus Phialophoropsis is resurrected to accommodate associates of the Xyloterini, including Phialophoropsis trypodendri from Trypodendron scabricollis and Phialophoropsis ferruginea comb. nov. from Trypodendron lineatum. Each of the ten named species was distinguished by ITS rDNA barcoding and morphology, and the ITS rDNA sequences of four other putative species were obtained with Ceratocystidaceae-specific primers and template DNA extracted from beetles or galleries. These results support the hypothesis that each ambrosia beetle species with large, complex mycangia carries its own fungal symbiont. Conidiophore morphology and phylogenetic analyses using 18S (SSU) rDNA and TEF1α DNA sequences suggest that these three fungal genera within the Ceratocystidaceae independently adapted to symbiosis with the three respective beetle tribes. In turn, the beetle genera with large, complex mycangia appear to have evolved from other genera in their respective tribes that have smaller, less selective mycangia and are associated with Raffaelea spp. (Ophiostomatales).</description><subject>Ambrosia - parasitology</subject><subject>ambrosia beetles</subject><subject>Ambrosia fungi</subject><subject>Ambrosiella beaveri</subject><subject>Animals</subject><subject>Ascomycota - classification</subject><subject>Ascomycota - genetics</subject><subject>Ascomycota - isolation & purification</subject><subject>Ascomycota - physiology</subject><subject>barcoding</subject><subject>Cluster Analysis</subject><subject>Corthylus</subject><subject>DNA, Fungal - chemistry</subject><subject>DNA, Fungal - genetics</subject><subject>DNA, Ribosomal - chemistry</subject><subject>DNA, Ribosomal - genetics</subject><subject>DNA, Ribosomal Spacer - chemistry</subject><subject>DNA, Ribosomal Spacer - genetics</subject><subject>fungi</subject><subject>Genetic Variation</subject><subject>internal transcribed spacers</subject><subject>Molecular Sequence Data</subject><subject>new combination</subject><subject>new genus</subject><subject>new species</subject><subject>Peptide Elongation Factor 1 - genetics</subject><subject>Phylogeny</subject><subject>polyphyly</subject><subject>Raffaelea</subject><subject>ribosomal DNA</subject><subject>RNA, Ribosomal, 18S - genetics</subject><subject>Scolytinae</subject><subject>Sequence Analysis, DNA</subject><subject>symbionts</subject><subject>Symbiosis</subject><subject>Trypodendron lineatum</subject><subject>Weevils - microbiology</subject><subject>Xyleborus</subject><subject>Xylosandrus</subject><issn>1878-6146</issn><issn>1878-6162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv3CAQx1HVqImSfIOq4thD1wVsY7hUqlZ9SZFySc6Ix7DLysYusGn2Y_Qbl82mObYcYDTzmwfzR-gtJQ0llH_cNX4fTZgbRmjfENEQwl6hCyoGseKUs9cvdsfP0XXOO1JPS1shhzfonPGOcyHoBfp9t00AeAMRksYh4rIFvK52me0hl-C0BQ1YJ3iKJMgL2BIeAOfDVAeIJePZ19ixSogOFqhXLHgMEfQGnqJ6MmnOQWMDUMbq-xXKFo86beADtvO0jPCIp4PVcRP0FTrzesxw_fxeovuvX-7W31c3t99-rD_frGwnWVlJL23vLaMOetGxgRpvWE87xo2UXWUsc12vWW967pgfpNMOHDct5dXhob1E7091lzT_3EMuagrZwjjqCPM-K1YXRvtWtMN_UTowJlvCZFfR7oTa-uOcwKslhUmng6JEHaVTO3WSTh2lU0SoKl1Ne_fcYW8mcC9Jf4WqwKcTAHUlDwGSyjZAtOBCqoIoN4d_d_gDCOGuuA</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Mayers, Chase G.</creator><creator>McNew, Douglas L.</creator><creator>Harrington, Thomas C.</creator><creator>Roeper, Richard A.</creator><creator>Fraedrich, Stephen W.</creator><creator>Biedermann, Peter H.W.</creator><creator>Castrillo, Louela A.</creator><creator>Reed, Sharon E.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>201511</creationdate><title>Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia</title><author>Mayers, Chase G. ; McNew, Douglas L. ; Harrington, Thomas C. ; Roeper, Richard A. ; Fraedrich, Stephen W. ; Biedermann, Peter H.W. ; Castrillo, Louela A. ; Reed, Sharon E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-9f9c5fc21de584271bfb251426b994c49c2d45a25b56d2f79daded6b31656dfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ambrosia - parasitology</topic><topic>ambrosia beetles</topic><topic>Ambrosia fungi</topic><topic>Ambrosiella beaveri</topic><topic>Animals</topic><topic>Ascomycota - classification</topic><topic>Ascomycota - genetics</topic><topic>Ascomycota - isolation & purification</topic><topic>Ascomycota - physiology</topic><topic>barcoding</topic><topic>Cluster Analysis</topic><topic>Corthylus</topic><topic>DNA, Fungal - chemistry</topic><topic>DNA, Fungal - genetics</topic><topic>DNA, Ribosomal - chemistry</topic><topic>DNA, Ribosomal - genetics</topic><topic>DNA, Ribosomal Spacer - chemistry</topic><topic>DNA, Ribosomal Spacer - genetics</topic><topic>fungi</topic><topic>Genetic Variation</topic><topic>internal transcribed spacers</topic><topic>Molecular Sequence Data</topic><topic>new combination</topic><topic>new genus</topic><topic>new species</topic><topic>Peptide Elongation Factor 1 - genetics</topic><topic>Phylogeny</topic><topic>polyphyly</topic><topic>Raffaelea</topic><topic>ribosomal DNA</topic><topic>RNA, Ribosomal, 18S - genetics</topic><topic>Scolytinae</topic><topic>Sequence Analysis, DNA</topic><topic>symbionts</topic><topic>Symbiosis</topic><topic>Trypodendron lineatum</topic><topic>Weevils - microbiology</topic><topic>Xyleborus</topic><topic>Xylosandrus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mayers, Chase G.</creatorcontrib><creatorcontrib>McNew, Douglas L.</creatorcontrib><creatorcontrib>Harrington, Thomas C.</creatorcontrib><creatorcontrib>Roeper, Richard A.</creatorcontrib><creatorcontrib>Fraedrich, Stephen W.</creatorcontrib><creatorcontrib>Biedermann, Peter H.W.</creatorcontrib><creatorcontrib>Castrillo, Louela A.</creatorcontrib><creatorcontrib>Reed, Sharon E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Fungal biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mayers, Chase G.</au><au>McNew, Douglas L.</au><au>Harrington, Thomas C.</au><au>Roeper, Richard A.</au><au>Fraedrich, Stephen W.</au><au>Biedermann, Peter H.W.</au><au>Castrillo, Louela A.</au><au>Reed, Sharon E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia</atitle><jtitle>Fungal biology</jtitle><addtitle>Fungal Biol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>119</volume><issue>11</issue><spage>1075</spage><epage>1092</epage><pages>1075-1092</pages><issn>1878-6146</issn><eissn>1878-6162</eissn><abstract>The genus Ambrosiella accommodates species of Ceratocystidaceae (Microascales) that are obligate, mutualistic symbionts of ambrosia beetles, but the genus appears to be polyphyletic and more diverse than previously recognized. In addition to Ambrosiella xylebori, Ambrosiella hartigii, Ambrosiella beaveri, and Ambrosiella roeperi, three new species of Ambrosiella are described from the ambrosia beetle tribe Xyleborini: Ambrosiella nakashimae sp. nov. from Xylosandrus amputatus, Ambrosiella batrae sp. nov. from Anisandrus sayi, and Ambrosiella grosmanniae sp. nov. from Xylosandrus germanus. The genus Meredithiella gen. nov. is created for symbionts of the tribe Corthylini, based on Meredithiella norrisii sp. nov. from Corthylus punctatissimus. The genus Phialophoropsis is resurrected to accommodate associates of the Xyloterini, including Phialophoropsis trypodendri from Trypodendron scabricollis and Phialophoropsis ferruginea comb. nov. from Trypodendron lineatum. Each of the ten named species was distinguished by ITS rDNA barcoding and morphology, and the ITS rDNA sequences of four other putative species were obtained with Ceratocystidaceae-specific primers and template DNA extracted from beetles or galleries. These results support the hypothesis that each ambrosia beetle species with large, complex mycangia carries its own fungal symbiont. Conidiophore morphology and phylogenetic analyses using 18S (SSU) rDNA and TEF1α DNA sequences suggest that these three fungal genera within the Ceratocystidaceae independently adapted to symbiosis with the three respective beetle tribes. In turn, the beetle genera with large, complex mycangia appear to have evolved from other genera in their respective tribes that have smaller, less selective mycangia and are associated with Raffaelea spp. (Ophiostomatales).</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>26466881</pmid><doi>10.1016/j.funbio.2015.08.002</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1878-6146 |
| ispartof | Fungal biology, 2015-11, Vol.119 (11), p.1075-1092 |
| issn | 1878-6146 1878-6162 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2000153837 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Ambrosia - parasitology ambrosia beetles Ambrosia fungi Ambrosiella beaveri Animals Ascomycota - classification Ascomycota - genetics Ascomycota - isolation & purification Ascomycota - physiology barcoding Cluster Analysis Corthylus DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Ribosomal - chemistry DNA, Ribosomal - genetics DNA, Ribosomal Spacer - chemistry DNA, Ribosomal Spacer - genetics fungi Genetic Variation internal transcribed spacers Molecular Sequence Data new combination new genus new species Peptide Elongation Factor 1 - genetics Phylogeny polyphyly Raffaelea ribosomal DNA RNA, Ribosomal, 18S - genetics Scolytinae Sequence Analysis, DNA symbionts Symbiosis Trypodendron lineatum Weevils - microbiology Xyleborus Xylosandrus |
| title | Three genera in the Ceratocystidaceae are the respective symbionts of three independent lineages of ambrosia beetles with large, complex mycangia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T11%3A47%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three%20genera%20in%20the%20Ceratocystidaceae%20are%20the%20respective%20symbionts%20of%20three%20independent%20lineages%20of%20ambrosia%20beetles%20with%20large,%20complex%20mycangia&rft.jtitle=Fungal%20biology&rft.au=Mayers,%20Chase%20G.&rft.date=2015-11&rft.volume=119&rft.issue=11&rft.spage=1075&rft.epage=1092&rft.pages=1075-1092&rft.issn=1878-6146&rft.eissn=1878-6162&rft_id=info:doi/10.1016/j.funbio.2015.08.002&rft_dat=%3Cproquest_cross%3E2000153837%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1722930294&rft_id=info:pmid/26466881&rft_els_id=S1878614615001397&rfr_iscdi=true |