Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities

Fifteen analogues of benzenepropanamine were synthesized and evaluated for their spermicidal as well as microbicidal activities against Trichomonas vaginalis and Candida spp. Several compounds showed appreciable dual activities. Compound 12 exhibited good spermicidal (MEC=0.1%) along with substantia...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-10, Vol.14 (19), p.6593-6600
Hauptverfasser:	Kiran Kumar, S.T.V.S., Sharma, Vishnu Lal, Kumar, Manish, Shukla, Praveen Kumar, Tiwari, Pratibha, Jain, Rajeev Kumar, Maikhuri, Jagdamba Prasad, Singh, Divya, Gupta, Gopal, Singh, Man Mohan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amines - chemistry Amines - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Anticandida agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antiparasitic agents Antitrichomonal Agents - chemical synthesis Antitrichomonal Agents - chemistry Antitrichomonal Agents - pharmacology Antitrichomonas Benzene Derivatives - chemistry Benzene Derivatives - pharmacology Benzenepropanamines Biological and medical sciences Candida Candida albicans - drug effects Cell Survival - drug effects Chemical Phenomena Chemistry, Physical Humans In Vitro Techniques Male Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Spectroscopy, Fourier Transform Infrared Spermatocidal Agents - chemical synthesis Spermatocidal Agents - chemistry Spermatocidal Agents - pharmacology Spermatozoa - drug effects Spermicides Structure-Activity Relationship Trichomonas vaginalis Trichomonas vaginalis - drug effects
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