Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy

[Display omitted] •Sarcocystis neurona (Sn) CDPK1 has an atypical small gatekeeper residue selectively inhibited by BKIs.•Evidence is provided that shows SnCDPK1 is a potential target for rational EPM drug development.•Bumped kinase inhibitors interfered with an early step in S. neurona tachyzoite h...

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Veröffentlicht in:	International journal for parasitology 2016-12, Vol.46 (13-14), p.871-880
Hauptverfasser:	Ojo, Kayode K., Dangoudoubiyam, Sriveny, Verma, Shiv K., Scheele, Suzanne, DeRocher, Amy E., Yeargan, Michelle, Choi, Ryan, Smith, Tess R., Rivas, Kasey L., Hulverson, Matthew A., Barrett, Lynn K., Fan, Erkang, Maly, Dustin J., Parsons, Marilyn, Dubey, Jitender P., Howe, Daniel K., Van Voorhis, Wesley C.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals antibodies brain Bumped kinase inhibitors Calcium-dependent protein kinase 1 Cell Line Cercopithecus aethiops Drug target drugs Encephalomyelitis - drug therapy Encephalomyelitis - parasitology enzyme inhibition Equine protozoal myeloencephalitis Female Gatekeeper residue growth retardation Horse Diseases - drug therapy Horse Diseases - parasitology Horses Interferon-gamma - genetics Male Mice Mice, Knockout parasites pharmacokinetics phenotype Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use protein kinases Protein Kinases - drug effects Rabbits Sarcocystis - drug effects Sarcocystis - enzymology Sarcocystis neurona Sarcocystosis - drug therapy Temperature therapeutics Toxoplasma - drug effects Toxoplasma - enzymology Toxoplasma gondii
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