A Translation-Like Cycle Is a Quality Control Checkpoint for Maturing 40S Ribosome Subunits

Assembly factors (AFs) prevent premature translation initiation on small (40S) ribosomal subunit assembly intermediates by blocking ligand binding. However, it is unclear how AFs are displaced from maturing 40S ribosomes, if or how maturing subunits are assessed for fidelity, and what prevents prema...

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Veröffentlicht in:	Cell 2012-07, Vol.150 (1), p.111-121
Hauptverfasser:	Strunk, Bethany S., Novak, Megan N., Young, Crystal L., Karbstein, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosinetriphosphatase Adenylate Kinase - metabolism ATP-Binding Cassette Transporters - metabolism Binding Sites Cell Cycle Proteins - metabolism Endoribonucleases - metabolism Eukaryotic Initiation Factors - metabolism GTP Phosphohydrolases - metabolism guanosinetriphosphatase messenger RNA Nuclear Proteins - metabolism Nucleoside-Triphosphatase - metabolism Protein Biosynthesis protein subunits quality control ribosomal proteins Ribosome Subunits, Large, Eukaryotic - metabolism Ribosome Subunits, Small, Eukaryotic - metabolism ribosomes Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism transfer RNA
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