IL6-Mediated Suppression of miR-200c Directs Constitutive Activation of Inflammatory Signaling Circuit Driving Transformation and Tumorigenesis

Abnormal inflammatory signaling activation occurs commonly in cancer cells. However, how it is initiated and maintained and its roles in early stages of tumorigensis are largely unknown. Here, we report that the monocyte-derived MCP-1-induced transformation of immortal breast epithelial cells is tri...

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Veröffentlicht in:	Molecular cell 2012-03, Vol.45 (6), p.777-789
Hauptverfasser:	Rokavec, Matjaz, Wu, Weilin, Luo, Jun-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Breast - cytology breast neoplasms carcinogenesis Cell Transformation, Neoplastic - genetics Chemokine CCL2 - genetics Chemokine CCL2 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Estrogen Receptor alpha - metabolism Female Heat Shock Transcription Factors Humans Inflammation - genetics Inflammation - metabolism interleukin-6 Interleukin-6 - genetics Interleukin-6 - metabolism JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Mice Mice, Transgenic MicroRNAs - metabolism mitogen-activated protein kinase Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism neoplasm cells NF-kappa B - genetics NF-kappa B - metabolism Promoter Regions, Genetic Signal Transduction - genetics STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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