Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors

Peripheral inflammation initiates changes in spinal nociceptive processing leading to hyperalgesia. Previously, we demonstrated that among 102 lipid species detected by LC-MS/MS analysis in rat spinal cord, the most notable increases that occur after intraplantar carrageenan are metabolites of 12-li...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (17), p.6721-6726
Hauptverfasser:	Gregus, Ann M, Doolen, Suzanne, Dumlao, Darren S, Buczynski, Matthew W, Takasusuki, Toshifumi, Fitzsimmons, Bethany L, Hua, Xiao-Ying, Taylor, Bradley K, Dennis, Edward A, Yaksh, Tony L
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid 8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism analogs & derivatives Animals Antagonists Arachidonate 12-Lipoxygenase Arachidonate 12-Lipoxygenase - metabolism Arachidonic acid Biological Sciences Calcium Calcium mobilization Capsaicin receptors carrageenan carrageenans Enzymes enzymology Heat Hyperalgesia Hyperalgesia - physiopathology Hyperesthesia Inflammation Inflammation - physiopathology Lipid metabolism metabolism Metabolites Mice Neurons Nordihydroguaiaretic acid Pain Pain perception physiology physiopathology Rats Receptors Sensory neurons Spinal cord Spinal Cord - enzymology Spinal Cord - metabolism Substance P Tactile stimuli Transient Receptor Potential Channels Transient Receptor Potential Channels - physiology TRPA1 Cation Channel TRPV Cation Channels TRPV Cation Channels - physiology
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