Regio- and stereoselective synthesis of new spirooxindoles via 1,3-dipolar cycloaddition reaction: Anticancer and molecular docking studies

Owing to their structural novelty and inherent three-dimensionality, spiro scaffolds have been shown indisputable promise as chemopreventive agents. A new series of heterocycles containing spirooxindole and pyrrolidine rings were synthesized by the 1,3-dipolar cycloaddition of an azomethine ylide, w...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2018-03, Vol.180, p.98-108
Hauptverfasser:	Lotfy, Gehad, El Ashry, El Sayed H., Said, Mohamed M., El Tamany, El Sayed, Abdel Aziz, Yasmine M., Al-Dhfyan, Abdullah, Al-Majid, Abdullah M., Barakat, Assem
Format:	Artikel
Sprache:	eng
Schlagworte:	1,3-Dipolar cycloaddition 5-Fluorouracil Amino acids Apoptosis Azomethine ylide Biotechnology Breast cancer Cancer Chemical synthesis Chemopreventive agents Chemotherapy Condensates Cycloaddition Cytotoxicity Gangrene L-Proline Leukemia MCF-12 normal mammary cell MDM2 protein MDM2-p53 Molecular chains Molecular docking Necrosis p53 Protein Proline Pyrrolidine Regioselectivity Spirooxindole Stereoselectivity Toxicity Tumor cell lines
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