Enzymatic amidation for industrial applications
[Display omitted] •Current state of enzymatic amide bond formation for industrial applications.•Case studies on the four main reported enzyme classes successfully scaled.•Opportunities to increase enzymatic amidation adoption for large scale processes. Nature has developed a robust toolbox for the f...
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| Veröffentlicht in: | Current opinion in chemical biology 2018-04, Vol.43, p.127-133 |
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| container_title | Current opinion in chemical biology |
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| creator | Dorr, Brent M Fuerst, Douglas E |
| description | [Display omitted]
•Current state of enzymatic amide bond formation for industrial applications.•Case studies on the four main reported enzyme classes successfully scaled.•Opportunities to increase enzymatic amidation adoption for large scale processes.
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art. |
| doi_str_mv | 10.1016/j.cbpa.2018.01.008 |
| format | Article |
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•Current state of enzymatic amide bond formation for industrial applications.•Case studies on the four main reported enzyme classes successfully scaled.•Opportunities to increase enzymatic amidation adoption for large scale processes.
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.</description><identifier>ISSN: 1367-5931</identifier><identifier>EISSN: 1879-0402</identifier><identifier>DOI: 10.1016/j.cbpa.2018.01.008</identifier><identifier>PMID: 29414531</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenosine Triphosphate - metabolism ; Amides - metabolism ; Biocatalysis ; Biotechnology - methods ; Enzymes - metabolism ; Industry</subject><ispartof>Current opinion in chemical biology, 2018-04, Vol.43, p.127-133</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6cabc55d89cec0010d3efbefdc40f98ed1a79711000e6028bae99af739273ffc3</citedby><cites>FETCH-LOGICAL-c356t-6cabc55d89cec0010d3efbefdc40f98ed1a79711000e6028bae99af739273ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1367593117301722$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29414531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorr, Brent M</creatorcontrib><creatorcontrib>Fuerst, Douglas E</creatorcontrib><title>Enzymatic amidation for industrial applications</title><title>Current opinion in chemical biology</title><addtitle>Curr Opin Chem Biol</addtitle><description>[Display omitted]
•Current state of enzymatic amide bond formation for industrial applications.•Case studies on the four main reported enzyme classes successfully scaled.•Opportunities to increase enzymatic amidation adoption for large scale processes.
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Amides - metabolism</subject><subject>Biocatalysis</subject><subject>Biotechnology - methods</subject><subject>Enzymes - metabolism</subject><subject>Industry</subject><issn>1367-5931</issn><issn>1879-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMotlb_AQ_So5fdzmz2K-BFSv2Aghc9h2wygZT9MtkV6l_v1qpHT_Ng3nvM_Bi7RogRMF_tYl31Kk4AyxgwBihP2BzLQkSQQnI6aZ4XUSY4zthFCDsAyJMyO2ezRKSYZhznbLVpP_eNGpxeqsaZSXTt0nZ-6VozhsE7VS9V39dOf6_CJTuzqg509TMX7O1h87p-irYvj8_r-22keZYPUa5VpbPMlEKTBkAwnGxF1ugUrCjJoCpEgTidRDkkZaVICGULLpKCW6v5gt0ee3vfvY8UBtm4oKmuVUvdGCQKIfIyQcEna3K0at-F4MnK3rtG-b1EkAdQcicPoOQBlASUE6gpdPPTP1YNmb_IL5nJcHc00PTlhyMvg3bUajLOkx6k6dx__V_gannJ</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Dorr, Brent M</creator><creator>Fuerst, Douglas E</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Enzymatic amidation for industrial applications</title><author>Dorr, Brent M ; Fuerst, Douglas E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6cabc55d89cec0010d3efbefdc40f98ed1a79711000e6028bae99af739273ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Amides - metabolism</topic><topic>Biocatalysis</topic><topic>Biotechnology - methods</topic><topic>Enzymes - metabolism</topic><topic>Industry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dorr, Brent M</creatorcontrib><creatorcontrib>Fuerst, Douglas E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in chemical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorr, Brent M</au><au>Fuerst, Douglas E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic amidation for industrial applications</atitle><jtitle>Current opinion in chemical biology</jtitle><addtitle>Curr Opin Chem Biol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>43</volume><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>1367-5931</issn><eissn>1879-0402</eissn><abstract>[Display omitted]
•Current state of enzymatic amide bond formation for industrial applications.•Case studies on the four main reported enzyme classes successfully scaled.•Opportunities to increase enzymatic amidation adoption for large scale processes.
Nature has developed a robust toolbox for the formation of amide bonds, enabling a variety of disconnections applicable to small molecule synthesis. In spite of this, the exploitation of biocatalytic techniques for industrial synthesis remains limited to a few very important cases. This review discusses previously demonstrated techniques for the biocatalytic synthesis of amide bonds, reviews examples of industrial scale-up of these techniques, and identifies a number of limitations to the scalability within the current state of the art.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>29414531</pmid><doi>10.1016/j.cbpa.2018.01.008</doi><tpages>7</tpages></addata></record> |
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| ispartof | Current opinion in chemical biology, 2018-04, Vol.43, p.127-133 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine Triphosphate - metabolism Amides - metabolism Biocatalysis Biotechnology - methods Enzymes - metabolism Industry |
| title | Enzymatic amidation for industrial applications |
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