Reproductive role of miRNA in the hypothalamic-pituitary axis
The hypothalamic-pituitary-gonadal (HPG) axis plays a critical role in regulating reproductive function. Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonadotrophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis...
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| Veröffentlicht in: | Molecular and cellular neuroscience 2018-04, Vol.88, p.130-137 |
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| creator | Cao, Chunyu Ding, Yifei Kong, Xiangjun Feng, Guangde Xiang, Wei Chen, Long Yang, Fang Zhang, Ke Chu, Mingxing Wang, Pingqing Zhang, Baoyun |
| description | The hypothalamic-pituitary-gonadal (HPG) axis plays a critical role in regulating reproductive function. Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonadotrophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion, ultimately affecting the animal's fertility. MicroRNAs are small, non-coding RNAs that are widely expressed throughout the brain and can fine-tune gene expression post-transcriptionally. Recently, growing evidence has unveiled the central position of miRNAs within a key regulatory process involving GnRH secretion and subsequent activation in the pituitary. Although transcriptional regulation of reproduction has been well studied, the post-transcriptional processes are less well understood. In this review, we elaborate comprehensively on the critical role of miRNAs in the reproductive process, including both temporal and spatial aspects. A better understanding of how miRNAs impact the neuroendocrine system may improve our knowledge of reproduction and provide novel targets for therapeutic development.
•The emerging role of miRNAs in the hypothalamic-pituitary axis for reproduction•Current expression of miRNAs in the hypothalamic-pituitary axis•Expanding the knowledge of miRNAs in the brain |
| doi_str_mv | 10.1016/j.mcn.2018.01.008 |
| format | Article |
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Gonadotropin-releasing hormone (GnRH), which is secreted by the hypothalamus, acts on pituitary gonadotrophs to stimulate luteinizing hormone (LH) and follicle-stimulating hormone (FSH) synthesis and secretion, ultimately affecting the animal's fertility. MicroRNAs are small, non-coding RNAs that are widely expressed throughout the brain and can fine-tune gene expression post-transcriptionally. Recently, growing evidence has unveiled the central position of miRNAs within a key regulatory process involving GnRH secretion and subsequent activation in the pituitary. Although transcriptional regulation of reproduction has been well studied, the post-transcriptional processes are less well understood. In this review, we elaborate comprehensively on the critical role of miRNAs in the reproductive process, including both temporal and spatial aspects. A better understanding of how miRNAs impact the neuroendocrine system may improve our knowledge of reproduction and provide novel targets for therapeutic development.
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| subjects | Animals Follicle Stimulating Hormone - metabolism Gene Expression Regulation - physiology GnRH neuron Gonadotropin-Releasing Hormone - metabolism Humans Hypothalamus - metabolism Hypothalamus-pituitary axis MicroRNAs - metabolism MiRNA Pituitary Gland - metabolism Reproduction |
| title | Reproductive role of miRNA in the hypothalamic-pituitary axis |
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