Posterior parietal cortex represents sensory history and mediates its effects on behaviour
A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information. How sensory history affects behaviour Recent sensory experiences, even when irrelevant to the current task at hand, bias memory and percepti...
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| Veröffentlicht in: | Nature (London) 2018-02, Vol.554 (7692), p.368-372 |
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| description | A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information.
How sensory history affects behaviour
Recent sensory experiences, even when irrelevant to the current task at hand, bias memory and perception in humans and monkeys. Carlos Brody and colleagues show that sensory stimulus history also influences the working memory of rats. Silencing the activity of the posterior parietal cortex (PPC), an area previously implicated in working memory, paradoxically improved the rats' performance in a memory and behaviour task—identifying and reporting the loudest of two auditory stimuli. This improvement was due to the selective reduction of the effects of previous sensory stimuli. Electrophysiological recordings showed that PPC neurons carried more information about sensory stimuli of previous trials than about stimuli of the current trial. These findings suggest a role for PPC in maintaining information on recent sensory history.
Many models of cognition and of neural computations posit the use and estimation of prior stimulus statistics
1
,
2
,
3
,
4
: it has long been known that working memory and perception are strongly impacted by previous sensory experience, even when that sensory history is not relevant to the current task at hand. Nevertheless, the neural mechanisms and regions of the brain that are necessary for computing and using such prior experience are unknown. Here we report that the posterior parietal cortex (PPC) is a critical locus for the representation and use of prior stimulus information. We trained rats in an auditory parametric working memory task, and found that they displayed substantial and readily quantifiable behavioural effects of sensory-stimulus history, similar to those observed in humans
5
,
6
and monkeys
7
. Earlier proposals that the PPC supports working memory
8
,
9
predict that optogenetic silencing of this region would impair behaviour in our working memory task. Contrary to this prediction, we found that silencing the PPC significantly improved performance. Quantitative analyses of behaviour revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed that PPC neurons carried far more information about the sensory stimuli of previous trials than about the stimuli of the current trial. Furthermore, for a given rat, the more information about prev |
| doi_str_mv | 10.1038/nature25510 |
| format | Article |
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How sensory history affects behaviour
Recent sensory experiences, even when irrelevant to the current task at hand, bias memory and perception in humans and monkeys. Carlos Brody and colleagues show that sensory stimulus history also influences the working memory of rats. Silencing the activity of the posterior parietal cortex (PPC), an area previously implicated in working memory, paradoxically improved the rats' performance in a memory and behaviour task—identifying and reporting the loudest of two auditory stimuli. This improvement was due to the selective reduction of the effects of previous sensory stimuli. Electrophysiological recordings showed that PPC neurons carried more information about sensory stimuli of previous trials than about stimuli of the current trial. These findings suggest a role for PPC in maintaining information on recent sensory history.
Many models of cognition and of neural computations posit the use and estimation of prior stimulus statistics
1
,
2
,
3
,
4
: it has long been known that working memory and perception are strongly impacted by previous sensory experience, even when that sensory history is not relevant to the current task at hand. Nevertheless, the neural mechanisms and regions of the brain that are necessary for computing and using such prior experience are unknown. Here we report that the posterior parietal cortex (PPC) is a critical locus for the representation and use of prior stimulus information. We trained rats in an auditory parametric working memory task, and found that they displayed substantial and readily quantifiable behavioural effects of sensory-stimulus history, similar to those observed in humans
5
,
6
and monkeys
7
. Earlier proposals that the PPC supports working memory
8
,
9
predict that optogenetic silencing of this region would impair behaviour in our working memory task. Contrary to this prediction, we found that silencing the PPC significantly improved performance. Quantitative analyses of behaviour revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed that PPC neurons carried far more information about the sensory stimuli of previous trials than about the stimuli of the current trial. Furthermore, for a given rat, the more information about previous trial sensory history in the neural firing rates of the PPC, the greater the behavioural effect of sensory history, suggesting a tight link between behaviour and PPC representations of stimulus history. Our results indicate that the PPC is a central component in the processing of sensory-stimulus history, and could enable further neurobiological investigation of long-standing questions regarding how perception and working memory are affected by prior sensory information.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature25510</identifier><identifier>PMID: 29414944</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/56 ; 631/378/1595/1636 ; 631/378/2649/1723 ; 64/86 ; Animal behavior ; Animal cognition ; Animal models ; Brain ; Cognition ; Cortex (parietal) ; Humanities and Social Sciences ; letter ; Mental task performance ; multidisciplinary ; Parietal lobes ; Perception ; Perception (Psychology) ; Physiological aspects ; Rats ; Science ; Sensory integration ; Sensory perception ; Sensory stimuli ; Short term memory ; Somatosensory cortex ; Stimuli</subject><ispartof>Nature (London), 2018-02, Vol.554 (7692), p.368-372</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. All rights reserved. 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 15, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-d7a32fb4bf9c18cb830ddce0d904ed0cec0b1184fbdc65a673b8ff0fc86dea8d3</citedby><cites>FETCH-LOGICAL-c557t-d7a32fb4bf9c18cb830ddce0d904ed0cec0b1184fbdc65a673b8ff0fc86dea8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nature25510$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nature25510$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29414944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akrami, Athena</creatorcontrib><creatorcontrib>Kopec, Charles D.</creatorcontrib><creatorcontrib>Diamond, Mathew E.</creatorcontrib><creatorcontrib>Brody, Carlos D.</creatorcontrib><title>Posterior parietal cortex represents sensory history and mediates its effects on behaviour</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information.
How sensory history affects behaviour
Recent sensory experiences, even when irrelevant to the current task at hand, bias memory and perception in humans and monkeys. Carlos Brody and colleagues show that sensory stimulus history also influences the working memory of rats. Silencing the activity of the posterior parietal cortex (PPC), an area previously implicated in working memory, paradoxically improved the rats' performance in a memory and behaviour task—identifying and reporting the loudest of two auditory stimuli. This improvement was due to the selective reduction of the effects of previous sensory stimuli. Electrophysiological recordings showed that PPC neurons carried more information about sensory stimuli of previous trials than about stimuli of the current trial. These findings suggest a role for PPC in maintaining information on recent sensory history.
Many models of cognition and of neural computations posit the use and estimation of prior stimulus statistics
1
,
2
,
3
,
4
: it has long been known that working memory and perception are strongly impacted by previous sensory experience, even when that sensory history is not relevant to the current task at hand. Nevertheless, the neural mechanisms and regions of the brain that are necessary for computing and using such prior experience are unknown. Here we report that the posterior parietal cortex (PPC) is a critical locus for the representation and use of prior stimulus information. We trained rats in an auditory parametric working memory task, and found that they displayed substantial and readily quantifiable behavioural effects of sensory-stimulus history, similar to those observed in humans
5
,
6
and monkeys
7
. Earlier proposals that the PPC supports working memory
8
,
9
predict that optogenetic silencing of this region would impair behaviour in our working memory task. Contrary to this prediction, we found that silencing the PPC significantly improved performance. Quantitative analyses of behaviour revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed that PPC neurons carried far more information about the sensory stimuli of previous trials than about the stimuli of the current trial. Furthermore, for a given rat, the more information about previous trial sensory history in the neural firing rates of the PPC, the greater the behavioural effect of sensory history, suggesting a tight link between behaviour and PPC representations of stimulus history. Our results indicate that the PPC is a central component in the processing of sensory-stimulus history, and could enable further neurobiological investigation of long-standing questions regarding how perception and working memory are affected by prior sensory information.</description><subject>13/56</subject><subject>631/378/1595/1636</subject><subject>631/378/2649/1723</subject><subject>64/86</subject><subject>Animal behavior</subject><subject>Animal cognition</subject><subject>Animal models</subject><subject>Brain</subject><subject>Cognition</subject><subject>Cortex (parietal)</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Mental task performance</subject><subject>multidisciplinary</subject><subject>Parietal lobes</subject><subject>Perception</subject><subject>Perception (Psychology)</subject><subject>Physiological aspects</subject><subject>Rats</subject><subject>Science</subject><subject>Sensory integration</subject><subject>Sensory 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aspects</topic><topic>Rats</topic><topic>Science</topic><topic>Sensory integration</topic><topic>Sensory perception</topic><topic>Sensory stimuli</topic><topic>Short term memory</topic><topic>Somatosensory cortex</topic><topic>Stimuli</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akrami, Athena</creatorcontrib><creatorcontrib>Kopec, Charles D.</creatorcontrib><creatorcontrib>Diamond, Mathew E.</creatorcontrib><creatorcontrib>Brody, Carlos D.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full 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D.</au><au>Diamond, Mathew E.</au><au>Brody, Carlos D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posterior parietal cortex represents sensory history and mediates its effects on behaviour</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2018-02-15</date><risdate>2018</risdate><volume>554</volume><issue>7692</issue><spage>368</spage><epage>372</epage><pages>368-372</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>A working memory task in rats demonstrates that the posterior parietal cortex is a critical locus for the representation and use of prior stimulus information.
How sensory history affects behaviour
Recent sensory experiences, even when irrelevant to the current task at hand, bias memory and perception in humans and monkeys. Carlos Brody and colleagues show that sensory stimulus history also influences the working memory of rats. Silencing the activity of the posterior parietal cortex (PPC), an area previously implicated in working memory, paradoxically improved the rats' performance in a memory and behaviour task—identifying and reporting the loudest of two auditory stimuli. This improvement was due to the selective reduction of the effects of previous sensory stimuli. Electrophysiological recordings showed that PPC neurons carried more information about sensory stimuli of previous trials than about stimuli of the current trial. These findings suggest a role for PPC in maintaining information on recent sensory history.
Many models of cognition and of neural computations posit the use and estimation of prior stimulus statistics
1
,
2
,
3
,
4
: it has long been known that working memory and perception are strongly impacted by previous sensory experience, even when that sensory history is not relevant to the current task at hand. Nevertheless, the neural mechanisms and regions of the brain that are necessary for computing and using such prior experience are unknown. Here we report that the posterior parietal cortex (PPC) is a critical locus for the representation and use of prior stimulus information. We trained rats in an auditory parametric working memory task, and found that they displayed substantial and readily quantifiable behavioural effects of sensory-stimulus history, similar to those observed in humans
5
,
6
and monkeys
7
. Earlier proposals that the PPC supports working memory
8
,
9
predict that optogenetic silencing of this region would impair behaviour in our working memory task. Contrary to this prediction, we found that silencing the PPC significantly improved performance. Quantitative analyses of behaviour revealed that this improvement was due to the selective reduction of the effects of prior sensory stimuli. Electrophysiological recordings showed that PPC neurons carried far more information about the sensory stimuli of previous trials than about the stimuli of the current trial. Furthermore, for a given rat, the more information about previous trial sensory history in the neural firing rates of the PPC, the greater the behavioural effect of sensory history, suggesting a tight link between behaviour and PPC representations of stimulus history. Our results indicate that the PPC is a central component in the processing of sensory-stimulus history, and could enable further neurobiological investigation of long-standing questions regarding how perception and working memory are affected by prior sensory information.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29414944</pmid><doi>10.1038/nature25510</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals; Nature Journals Online |
| subjects | 13/56 631/378/1595/1636 631/378/2649/1723 64/86 Animal behavior Animal cognition Animal models Brain Cognition Cortex (parietal) Humanities and Social Sciences letter Mental task performance multidisciplinary Parietal lobes Perception Perception (Psychology) Physiological aspects Rats Science Sensory integration Sensory perception Sensory stimuli Short term memory Somatosensory cortex Stimuli |
| title | Posterior parietal cortex represents sensory history and mediates its effects on behaviour |
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