Phenotypic Characterization of Resistant Val super(36) Variants of Hepatitis C Virus NS3-4A Serine Protease

In patients chronically infected with hepatitis C virus (HCV) strains of genotype 1, rapid and dramatic antiviral activity has been observed with telaprevir (VX-950), a highly selective and potent inhibitor of the HCV NS3-4A serine protease. HCV variants with substitutions in the NS3 protease domain...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2008-01, Vol.52 (1), p.110-120
Hauptverfasser:	Zhou, Yi, Bartels, Doug J, Hanzelka, Brian L, Mueh, Ute, Wei, Yunyi, Chu, Hui-May, Tigges, Ann M, Brennan, Debra L, Rao, BGovinda, Swenson, Lora, Kwong, Ann D, Lin, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Hepatitis C virus
Online-Zugang:	Volltext
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