Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand
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Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2008-02, Vol.52 (2), p.586-597 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01172-07</identifier><identifier>PMID: 18056278</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adenine ; Adenine - analogs & derivatives ; Adenine - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cytosine ; Cytosine - analogs & derivatives ; Cytosine - pharmacology ; DNA Primers ; DNA, Viral ; DNA, Viral - biosynthesis ; DNA, Viral - drug effects ; DNA, Viral - genetics ; DNA-Directed DNA Polymerase ; Medical sciences ; Nucleic Acid Synthesis Inhibitors ; Organophosphonates ; Organophosphonates - pharmacology ; Pharmacology. Drug treatments ; Templates, Genetic ; Vaccinia virus ; Vaccinia virus - drug effects ; Vaccinia virus - genetics ; Vaccinia virus - physiology ; Virus Replication</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2008-02, Vol.52 (2), p.586-597</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008 American Society for Microbiology</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a502t-894565a40fb37c2c4873fe86005d0e8bd802679bafec5bd270b8b505b8acb13c3</citedby><cites>FETCH-LOGICAL-a502t-894565a40fb37c2c4873fe86005d0e8bd802679bafec5bd270b8b505b8acb13c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224733/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224733/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20278327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18056278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAGEE, Wendy C</creatorcontrib><creatorcontrib>ALDERN, Kathy A</creatorcontrib><creatorcontrib>HOSTETLER, Karl Y</creatorcontrib><creatorcontrib>EVANS, David H</creatorcontrib><title>Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral Agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cytosine</topic><topic>Cytosine - analogs & derivatives</topic><topic>Cytosine - pharmacology</topic><topic>DNA Primers</topic><topic>DNA, Viral</topic><topic>DNA, Viral - biosynthesis</topic><topic>DNA, Viral - drug effects</topic><topic>DNA, Viral - genetics</topic><topic>DNA-Directed DNA Polymerase</topic><topic>Medical sciences</topic><topic>Nucleic Acid Synthesis Inhibitors</topic><topic>Organophosphonates</topic><topic>Organophosphonates - pharmacology</topic><topic>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>18056278</pmid><doi>10.1128/AAC.01172-07</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
subjects | Adenine Adenine - analogs & derivatives Adenine - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - pharmacology Biological and medical sciences Cytosine Cytosine - analogs & derivatives Cytosine - pharmacology DNA Primers DNA, Viral DNA, Viral - biosynthesis DNA, Viral - drug effects DNA, Viral - genetics DNA-Directed DNA Polymerase Medical sciences Nucleic Acid Synthesis Inhibitors Organophosphonates Organophosphonates - pharmacology Pharmacology. Drug treatments Templates, Genetic Vaccinia virus Vaccinia virus - drug effects Vaccinia virus - genetics Vaccinia virus - physiology Virus Replication |
title | Cidofovir and (S)-9-[3-Hydroxy-(2-Phosphonomethoxy)Propyl]Adenine Are Highly Effective Inhibitors of Vaccinia Virus DNA Polymerase When Incorporated into the Template Strand |
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