Physicochemical Characterization, Glycosylation Pattern and Biosimilarity Assessment of the Fusion Protein Etanercept

Etanercept is a soluble fusion protein of the tumor necrosis factor receptor (TNFR) extracellular domain, linked to an Fc part of IgG1. It possesses three N- and 13 O-glycosylation sites. Due to its complex structure, an analytical challenge is facing the development and approval of biosimilars. In...

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Veröffentlicht in:	The Protein Journal 2018-04, Vol.37 (2), p.164-179
Hauptverfasser:	Montacir, Othman, Montacir, Houda, Springer, Andreas, Hinderlich, Stephan, Mahboudi, Fereidoun, Saadati, Amirhossein, Parr, Maria Kristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytics Animal Anatomy Biochemistry Biological products Bioorganic Chemistry Biosimilar Pharmaceuticals - analysis Biosimilar Pharmaceuticals - chemistry Chemistry Chemistry and Materials Science Etanercept Etanercept - chemistry Fusion protein Glycan Glycopeptides Glycopeptides - analysis Glycopeptides - chemistry Glycoproteins Glycosylation Histology Immunoglobulin G Ionic mobility Lysine Mass Spectrometry Morphology N-glycans Neutralization Organic Chemistry Oxidation Polysaccharides Polysaccharides - analysis Polysaccharides - chemistry Post-translation Quality management Spectrometry Studies Tumor necrosis factor Tumor necrosis factor receptors
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