Two-Pore Minimum Physiologically-based Pharmacokinetic Model to Describe the Disposition of Therapeutic Monoclonal IgG Antibody in Humans

Purpose The aim of this study was to develop a two-pore minimum physiologically-based pharmacokinetic (mPBPK) model in describing the pharmacokinetic (PK) of therapeutic monoclonal antibody (TMAb) in human subjects. Methods PK data used in this study were endogenous/exogenous native IgG and two TMAb...

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Veröffentlicht in:	Pharmaceutical research 2018-03, Vol.35 (3), p.47-11, Article 47
Hauptverfasser:	Hardiansyah, Deni, Ng, Chee Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized - pharmacokinetics Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Capillaries - metabolism Capillary Permeability Endocytosis Half-Life Health aspects Healthy Volunteers Human subjects Humans Immunoglobulin G Immunoglobulin G - pharmacology Immunoglobulin G - therapeutic use Immunotherapy Intestinal Mucosa - blood supply Intestinal Mucosa - metabolism Medical Law Metabolic Clearance Rate Metabolism, Inborn Errors - drug therapy Models, Biological Monoclonal antibodies Palivizumab Palivizumab - pharmacokinetics Pharmacokinetics Pharmacology/Toxicology Pharmacy Research Paper Salvage
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