Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy

We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (16), p.1996-1999
Hauptverfasser:	Li, Yang, Kang, Tianyi, Wu, Yujiao, Chen, Yuwen, Zhu, Jiao, Gou, Maling
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Chemical compounds Drugs Esters Fatty acids
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container_end_page	1999
container_issue	16
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container_title	Chemical communications (Cambridge, England)
container_volume	54
creator	Li, Yang Kang, Tianyi Wu, Yujiao Chen, Yuwen Zhu, Jiao Gou, Maling
description	We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.
doi_str_mv	10.1039/c8cc00639c
format	Article
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identifier	ISSN: 1359-7345
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language	eng
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source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Anticancer properties Chemical compounds Drugs Esters Fatty acids
title	Carbonate esters turn camptothecin-unsaturated fatty acid prodrugs into nanomedicines for cancer therapy
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