Selectivity Modulation and Structure of α/aza‐β3 Cyclic Antimicrobial Peptides

Potent and selective antimicrobial cyclic pseudopeptides (ACPPs) mixing α‐ and aza‐β3‐amino acids were developed. Cyclopseudopeptide sequences were designed to investigate the impact of some intrinsic molecular parameters on their biological activities. Fine changes in the nature of the side chains...

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Veröffentlicht in:	Chemistry : a European journal 2018-04, Vol.24 (23), p.6191-6201
Hauptverfasser:	Laurencin, Mathieu, Simon, Matthieu, Fleury, Yannick, Baudy‐Floc'h, Michèle, Bondon, Arnaud, Legrand, Baptiste
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Antimicrobial peptides aza amino acids Biological activity Chains Chemistry cyclic peptides Peptides peptidomimetics Selectivity
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