Design, Synthesis, and Anti‐HIV‐1 Evaluation of a Novel Series of 1,2,3,4‐Tetrahydropyrimidine‐5‐Carboxylic Acid Derivatives

A series of tetrahydropyrimidine derivatives (2a – 2l) were designed, synthesized, and screened for anti‐HIV‐1 properties based on the structures of HIV‐1 gp41 binding site inhibitors, NB‐2 and NB‐64. A computational study was performed to predict the pharmacodynamics, pharmacokinetics, and drug‐lik...

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Veröffentlicht in:	Chemistry & biodiversity 2018-04, Vol.15 (4), p.e1700502-n/a
Hauptverfasser:	Sepehri, Saghi, Soleymani, Sepehr, Zabihollahi, Rezvan, Aghasadeghi, Mohammad R., Sadat, Mehdi, Saghaie, Lotfollah, Memarian, Hamid R., Fassihi, Afshin
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐HIV agents Binding sites Carboxylic acids Chemical bonds Computer applications Derivatives Docking drug likeness Glycoprotein gp41 gp41 HIV Human immunodeficiency virus Hydrogen bonds Inhibitors molecular docking Molecular weight Pharmacodynamics Pharmacokinetics Pharmacology Physiochemistry Synthesis tetrahydropyrimidine derivatives
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