Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction
Background Although a lot of studies have shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia...
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| Veröffentlicht in: | Aging clinical and experimental research 2018-10, Vol.30 (10), p.1211-1215 |
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| creator | Li, Li Ma, Yi Shang, Xiao-ming Hong, Ye Wang, Jian-hui Tan, Zheng Wang, Ya-jun Geng, Xue-bin |
| description | Background
Although a lot of studies have shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia and short-term outcomes of elderly patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods
Six hundred and seventy-three elderly patients (≥ 60 years) were divided into high-SUA-level group (group H:
N
= 168) and low-SUA-level group (group L:
N
= 505) according to the SUA levels on admission. The following primary end points were evaluated within 30 days of AMI. The adverse events included postoperative angina pectoris, heart failure (Killip class ≥ II), and death. The comparisons were made between two groups in clinical and angiographic characteristics.
Results
The incidences of postoperative angina pectoris, heart failure, and the total adverse cardiovascular events were significantly higher in group H than in group L. But the incidence of death was similar between groups. In group H, heart rate (HR), systolic and diastolic blood pressure, SUA, homocysteine (HCY), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and creatine kinase myocardial band (CKMB) peak were clearly higher compared with those in group L. The results of logistic regression showed that the incidence of 30-day adverse events was closely related to TG, HCY and SUA.
Conclusions
An elevated SUA level may be related to the short-term outcomes and seems to be an independent predictor of 30-day cardiovascular events in elderly patients with STEMI. |
| doi_str_mv | 10.1007/s40520-018-0903-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1999199903</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2349119118</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-6ac1fb1bc5d72c960ab5840865062ff295f185f8ef2f53a3f09f2e0ebb13650d3</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhkVJaL76A3opglx6cTMj2bvWsYQ0KQRySc5ClkddLba1lWTC_vtqcZqUQEFCo5ln3hF6GfuM8A0B1lephkZABdhWoEBW8gM7xXXJtBLV0T_xCTtLaQtQY7l8ZCdC1YhStKfM3-13FOfoLY3ecJ-4SSlYbzL1_NnnDU-bEHOVKY48zNmGkRL3E6ehpzjs-c5kT1NOC2zsnImP-2BN7L0ZCulMtNmH6YIdOzMk-vRynrOnHzeP13fV_cPtz-vv95WVa5GrlbHoOuxs06-FVSswXdPW0K4aWAnnhGocto1ryQnXSCMdKCcIqOtQFqaX5-zroruL4fdMKevRJ0vDYCYKc9KolDpskAW9fIduwxyn8jotZK0Qy2oLhQtlY0gpktO76EcT9xpBH3zQiw-6-KAPPuiD8pcX5bkbqX_t-PvxBRALkEpp-kXxbfT_Vf8A70mUKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2349119118</pqid></control><display><type>article</type><title>Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Li, Li ; Ma, Yi ; Shang, Xiao-ming ; Hong, Ye ; Wang, Jian-hui ; Tan, Zheng ; Wang, Ya-jun ; Geng, Xue-bin</creator><creatorcontrib>Li, Li ; Ma, Yi ; Shang, Xiao-ming ; Hong, Ye ; Wang, Jian-hui ; Tan, Zheng ; Wang, Ya-jun ; Geng, Xue-bin</creatorcontrib><description>Background
Although a lot of studies have shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia and short-term outcomes of elderly patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods
Six hundred and seventy-three elderly patients (≥ 60 years) were divided into high-SUA-level group (group H:
N
= 168) and low-SUA-level group (group L:
N
= 505) according to the SUA levels on admission. The following primary end points were evaluated within 30 days of AMI. The adverse events included postoperative angina pectoris, heart failure (Killip class ≥ II), and death. The comparisons were made between two groups in clinical and angiographic characteristics.
Results
The incidences of postoperative angina pectoris, heart failure, and the total adverse cardiovascular events were significantly higher in group H than in group L. But the incidence of death was similar between groups. In group H, heart rate (HR), systolic and diastolic blood pressure, SUA, homocysteine (HCY), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and creatine kinase myocardial band (CKMB) peak were clearly higher compared with those in group L. The results of logistic regression showed that the incidence of 30-day adverse events was closely related to TG, HCY and SUA.
Conclusions
An elevated SUA level may be related to the short-term outcomes and seems to be an independent predictor of 30-day cardiovascular events in elderly patients with STEMI.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-018-0903-3</identifier><identifier>PMID: 29411328</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Angina pectoris ; Biomarkers - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Electrocardiography ; Female ; Geriatrics/Gerontology ; Health risk assessment ; Heart attacks ; Heart failure ; Homocysteine - blood ; Humans ; Hyperuricemia - epidemiology ; Incidence ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - mortality ; Original Article ; Risk Factors ; Short term ; Triglycerides - blood</subject><ispartof>Aging clinical and experimental research, 2018-10, Vol.30 (10), p.1211-1215</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-6ac1fb1bc5d72c960ab5840865062ff295f185f8ef2f53a3f09f2e0ebb13650d3</citedby><cites>FETCH-LOGICAL-c372t-6ac1fb1bc5d72c960ab5840865062ff295f185f8ef2f53a3f09f2e0ebb13650d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-018-0903-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-018-0903-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29411328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Ma, Yi</creatorcontrib><creatorcontrib>Shang, Xiao-ming</creatorcontrib><creatorcontrib>Hong, Ye</creatorcontrib><creatorcontrib>Wang, Jian-hui</creatorcontrib><creatorcontrib>Tan, Zheng</creatorcontrib><creatorcontrib>Wang, Ya-jun</creatorcontrib><creatorcontrib>Geng, Xue-bin</creatorcontrib><title>Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Although a lot of studies have shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia and short-term outcomes of elderly patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods
Six hundred and seventy-three elderly patients (≥ 60 years) were divided into high-SUA-level group (group H:
N
= 168) and low-SUA-level group (group L:
N
= 505) according to the SUA levels on admission. The following primary end points were evaluated within 30 days of AMI. The adverse events included postoperative angina pectoris, heart failure (Killip class ≥ II), and death. The comparisons were made between two groups in clinical and angiographic characteristics.
Results
The incidences of postoperative angina pectoris, heart failure, and the total adverse cardiovascular events were significantly higher in group H than in group L. But the incidence of death was similar between groups. In group H, heart rate (HR), systolic and diastolic blood pressure, SUA, homocysteine (HCY), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and creatine kinase myocardial band (CKMB) peak were clearly higher compared with those in group L. The results of logistic regression showed that the incidence of 30-day adverse events was closely related to TG, HCY and SUA.
Conclusions
An elevated SUA level may be related to the short-term outcomes and seems to be an independent predictor of 30-day cardiovascular events in elderly patients with STEMI.</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Biomarkers - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Health risk assessment</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hyperuricemia - epidemiology</subject><subject>Incidence</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - mortality</subject><subject>Original Article</subject><subject>Risk Factors</subject><subject>Short term</subject><subject>Triglycerides - blood</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1r3DAQhkVJaL76A3opglx6cTMj2bvWsYQ0KQRySc5ClkddLba1lWTC_vtqcZqUQEFCo5ln3hF6GfuM8A0B1lephkZABdhWoEBW8gM7xXXJtBLV0T_xCTtLaQtQY7l8ZCdC1YhStKfM3-13FOfoLY3ecJ-4SSlYbzL1_NnnDU-bEHOVKY48zNmGkRL3E6ehpzjs-c5kT1NOC2zsnImP-2BN7L0ZCulMtNmH6YIdOzMk-vRynrOnHzeP13fV_cPtz-vv95WVa5GrlbHoOuxs06-FVSswXdPW0K4aWAnnhGocto1ryQnXSCMdKCcIqOtQFqaX5-zroruL4fdMKevRJ0vDYCYKc9KolDpskAW9fIduwxyn8jotZK0Qy2oLhQtlY0gpktO76EcT9xpBH3zQiw-6-KAPPuiD8pcX5bkbqX_t-PvxBRALkEpp-kXxbfT_Vf8A70mUKg</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Li, Li</creator><creator>Ma, Yi</creator><creator>Shang, Xiao-ming</creator><creator>Hong, Ye</creator><creator>Wang, Jian-hui</creator><creator>Tan, Zheng</creator><creator>Wang, Ya-jun</creator><creator>Geng, Xue-bin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction</title><author>Li, Li ; Ma, Yi ; Shang, Xiao-ming ; Hong, Ye ; Wang, Jian-hui ; Tan, Zheng ; Wang, Ya-jun ; Geng, Xue-bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-6ac1fb1bc5d72c960ab5840865062ff295f185f8ef2f53a3f09f2e0ebb13650d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Angina pectoris</topic><topic>Biomarkers - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Health risk assessment</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hyperuricemia - epidemiology</topic><topic>Incidence</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - mortality</topic><topic>Original Article</topic><topic>Risk Factors</topic><topic>Short term</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Ma, Yi</creatorcontrib><creatorcontrib>Shang, Xiao-ming</creatorcontrib><creatorcontrib>Hong, Ye</creatorcontrib><creatorcontrib>Wang, Jian-hui</creatorcontrib><creatorcontrib>Tan, Zheng</creatorcontrib><creatorcontrib>Wang, Ya-jun</creatorcontrib><creatorcontrib>Geng, Xue-bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Li</au><au>Ma, Yi</au><au>Shang, Xiao-ming</au><au>Hong, Ye</au><au>Wang, Jian-hui</au><au>Tan, Zheng</au><au>Wang, Ya-jun</au><au>Geng, Xue-bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>30</volume><issue>10</issue><spage>1211</spage><epage>1215</epage><pages>1211-1215</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Although a lot of studies have shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia and short-term outcomes of elderly patients with acute ST-segment elevation myocardial infarction (STEMI).
Methods
Six hundred and seventy-three elderly patients (≥ 60 years) were divided into high-SUA-level group (group H:
N
= 168) and low-SUA-level group (group L:
N
= 505) according to the SUA levels on admission. The following primary end points were evaluated within 30 days of AMI. The adverse events included postoperative angina pectoris, heart failure (Killip class ≥ II), and death. The comparisons were made between two groups in clinical and angiographic characteristics.
Results
The incidences of postoperative angina pectoris, heart failure, and the total adverse cardiovascular events were significantly higher in group H than in group L. But the incidence of death was similar between groups. In group H, heart rate (HR), systolic and diastolic blood pressure, SUA, homocysteine (HCY), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and creatine kinase myocardial band (CKMB) peak were clearly higher compared with those in group L. The results of logistic regression showed that the incidence of 30-day adverse events was closely related to TG, HCY and SUA.
Conclusions
An elevated SUA level may be related to the short-term outcomes and seems to be an independent predictor of 30-day cardiovascular events in elderly patients with STEMI.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29411328</pmid><doi>10.1007/s40520-018-0903-3</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Aged Angina pectoris Biomarkers - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Electrocardiography Female Geriatrics/Gerontology Health risk assessment Heart attacks Heart failure Homocysteine - blood Humans Hyperuricemia - epidemiology Incidence Logistic Models Male Medicine Medicine & Public Health Middle Aged Myocardial Infarction - blood Myocardial Infarction - mortality Original Article Risk Factors Short term Triglycerides - blood |
| title | Hyperuricemia is associated with short-term outcomes in elderly patients with acute myocardial infarction |
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