The construction of recombinant Lactobacillus casei expressing BVDV E2 protein and its immune response in mice

•Construction of Bovine Viral Diarrhea Virus (BVDV) E2 gene expressing pELX1-E2 system in L. casei.•Strong humoral, cellular and local immune responses was found in mice induced by the recombinant strain.•Intranasal administration was found most effective route of vaccination.•Active protection foll...

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Veröffentlicht in:	Journal of biotechnology 2018-03, Vol.270, p.51-60
Hauptverfasser:	Bhuyan, Anjuman Ara, Memon, Atta Muhammad, Bhuiyan, Ali Akbar, Zhonghua, Li, Zhang, Bingzhou, Ye, Shiyi, Mengying, Li, He, Qi-Gai
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Administration, Oral Animals Antibodies, Viral - blood BVDV Diarrhea Viruses, Bovine Viral - genetics Diarrhea Viruses, Bovine Viral - immunology Diarrhea Viruses, Bovine Viral - metabolism E2 protein Genetic Engineering Immune responses Immunization Interferon-gamma - metabolism Lactobacillus casei Lactobacillus casei - genetics Lactobacillus casei - immunology Lactobacillus casei - metabolism Mice Mice, Inbred BALB C Mucosal vaccine Protection Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral Envelope Proteins - metabolism
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