Association between obesity and bladder cancer recurrence: A meta-analysis
The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence. Relevant English-language studies were identified by searching PubMed® up to November 1, 20...
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| Veröffentlicht in: | Clinica chimica acta 2018-05, Vol.480, p.41-46 |
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| container_title | Clinica chimica acta |
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| creator | Lin, Yadi Wang, Yunyan Wu, Qin Jin, Hua Ma, Gaoxiang Liu, Hanting Wang, Meilin Zhang, Zhengdong Chu, Haiyan |
| description | The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence.
Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed.
Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36–2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05–1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97–1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02).
This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
•A tight relationship between obesity and bladder cancer prognosis is proposed.•Obese patients get higher rate of bladder cancer recurrence compared to patients with normal weight.•Obesity is not associated with postoperative survival of bladder cancer. |
| doi_str_mv | 10.1016/j.cca.2018.01.039 |
| format | Article |
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Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed.
Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36–2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05–1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97–1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02).
This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
•A tight relationship between obesity and bladder cancer prognosis is proposed.•Obese patients get higher rate of bladder cancer recurrence compared to patients with normal weight.•Obesity is not associated with postoperative survival of bladder cancer.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2018.01.039</identifier><identifier>PMID: 29408169</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bladder cancer ; Obesity ; Recurrence ; Survival</subject><ispartof>Clinica chimica acta, 2018-05, Vol.480, p.41-46</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-7c3aebec0f1d8bea8c7ffb592a1528f96cf1736f282ab1cea39a2dc767743363</citedby><cites>FETCH-LOGICAL-c353t-7c3aebec0f1d8bea8c7ffb592a1528f96cf1736f282ab1cea39a2dc767743363</cites><orcidid>0000-0003-0190-8574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898118300470$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29408169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yadi</creatorcontrib><creatorcontrib>Wang, Yunyan</creatorcontrib><creatorcontrib>Wu, Qin</creatorcontrib><creatorcontrib>Jin, Hua</creatorcontrib><creatorcontrib>Ma, Gaoxiang</creatorcontrib><creatorcontrib>Liu, Hanting</creatorcontrib><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Zhang, Zhengdong</creatorcontrib><creatorcontrib>Chu, Haiyan</creatorcontrib><title>Association between obesity and bladder cancer recurrence: A meta-analysis</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence.
Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed.
Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36–2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05–1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97–1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02).
This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
•A tight relationship between obesity and bladder cancer prognosis is proposed.•Obese patients get higher rate of bladder cancer recurrence compared to patients with normal weight.•Obesity is not associated with postoperative survival of bladder cancer.</description><subject>Bladder cancer</subject><subject>Obesity</subject><subject>Recurrence</subject><subject>Survival</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqXwAWxQlmwSPHGa2LCqKp6qxKZ7a2JPJFd5FDsF9e9xVWDJamakc680h7Fr4BlwKO82mTGY5RxkxiHjQp2wKchKpKJQ-Smbcs5VKpWECbsIYRPPgpdwzia5KriEUk3Z2yKEwTgc3dAnNY1fRH0y1BTcuE-wt0ndorXkE4O9icOT2XlPcb9PFklHI6bYY7sPLlyyswbbQFc_c8bWT4_r5Uu6en9-XS5WqRFzMaaVEUg1Gd6AlTWhNFXT1HOVI8xz2ajSNFCJsslljjUYQqEwt6Yqq6oQohQzdnus3frhY0dh1J0LhtoWexp2QYNSClTERUThiBo_hOCp0VvvOvR7DVwfDOqNjgb1waDmoKPBmLn5qd_VHdm_xK-yCDwcAYo_fjryOhh3EGJdlDNqO7h_6r8BW3WBkg</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Lin, Yadi</creator><creator>Wang, Yunyan</creator><creator>Wu, Qin</creator><creator>Jin, Hua</creator><creator>Ma, Gaoxiang</creator><creator>Liu, Hanting</creator><creator>Wang, Meilin</creator><creator>Zhang, Zhengdong</creator><creator>Chu, Haiyan</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0190-8574</orcidid></search><sort><creationdate>201805</creationdate><title>Association between obesity and bladder cancer recurrence: A meta-analysis</title><author>Lin, Yadi ; Wang, Yunyan ; Wu, Qin ; Jin, Hua ; Ma, Gaoxiang ; Liu, Hanting ; Wang, Meilin ; Zhang, Zhengdong ; Chu, Haiyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-7c3aebec0f1d8bea8c7ffb592a1528f96cf1736f282ab1cea39a2dc767743363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bladder cancer</topic><topic>Obesity</topic><topic>Recurrence</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yadi</creatorcontrib><creatorcontrib>Wang, Yunyan</creatorcontrib><creatorcontrib>Wu, Qin</creatorcontrib><creatorcontrib>Jin, Hua</creatorcontrib><creatorcontrib>Ma, Gaoxiang</creatorcontrib><creatorcontrib>Liu, Hanting</creatorcontrib><creatorcontrib>Wang, Meilin</creatorcontrib><creatorcontrib>Zhang, Zhengdong</creatorcontrib><creatorcontrib>Chu, Haiyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yadi</au><au>Wang, Yunyan</au><au>Wu, Qin</au><au>Jin, Hua</au><au>Ma, Gaoxiang</au><au>Liu, Hanting</au><au>Wang, Meilin</au><au>Zhang, Zhengdong</au><au>Chu, Haiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between obesity and bladder cancer recurrence: A meta-analysis</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2018-05</date><risdate>2018</risdate><volume>480</volume><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>The association between obesity and bladder cancer prognosis is not well-defined. This meta-analysis was performed to explore whether obesity is related to overall survival (OS) and bladder cancer recurrence.
Relevant English-language studies were identified by searching PubMed® up to November 1, 2017. We pooled the hazard ratios (HR) and 95% confidence intervals (CIs) using a random effect model. Dose-response relationship, subgroup and sensitivity were also analyzed.
Eleven studies were included. Recurrence rate of bladder cancer was significantly greater in obese (HR = 1.76, 95% CI: 1.36–2.28) vs normal weight patients. Stratification analysis showed that females had higher recurrence risk than males (HR = 1.17, 95% CI: 1.05–1.31). Obesity was not significantly associated with bladder cancer OS (HR = 1.21, 95% CI: 0.97–1.52). Dose-response relationship analysis revealed a linear association between BMI and risk of recurrence. Each one kg/m2 increase in BMI was related to a 1.3% increased risk of bladder cancer recurrence (HR = 1.01, 95% CI = 1.01 to 1.02).
This meta-analysis revealed that obesity may be a risk factor for bladder cancer recurrence.
•A tight relationship between obesity and bladder cancer prognosis is proposed.•Obese patients get higher rate of bladder cancer recurrence compared to patients with normal weight.•Obesity is not associated with postoperative survival of bladder cancer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29408169</pmid><doi>10.1016/j.cca.2018.01.039</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0190-8574</orcidid></addata></record> |
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| ispartof | Clinica chimica acta, 2018-05, Vol.480, p.41-46 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Bladder cancer Obesity Recurrence Survival |
| title | Association between obesity and bladder cancer recurrence: A meta-analysis |
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