Interleukin-6 potentiates FcεRI-induced PGD2 biosynthesis and induces VEGF from human in situ-matured skin mast cells

Interleukin-6 is a gp130 utilizing cytokine that is consistently associated with allergic diseases like asthma and urticaria in humans where mast cells are known to play a critical role. However, the role of IL-6 in allergic disease in not known. IL-6 was reported to enhance degranulation of in vitr...

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Veröffentlicht in:	Biochimica et biophysica acta 2018-05, Vol.1862 (5), p.1069-1078
Hauptverfasser:	McHale, Cody, Mohammed, Zahraa, Deppen, Juline, Gomez, Gregorio
Format:	Artikel
Sprache:	eng
Schlagworte:	COX‑2 IL-6 Mast cells Prostaglandin D2 STAT3 VEGF
Online-Zugang:	Volltext
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