The Synthesized Plant Metabolite 3,4,5-Tri‑O‑Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells

The plant metabolite 3,4,5-tri-O-galloylquinic acid methyl ester (TGAME, compound 6) was synthesized, and its potential effect on calcium oxalate monohydrate (COM) crystal binding to the surface of Madin–Darby canine kidney cells type I (MDCKI) and crystal growth in a Drosophila melanogaster Malpigh...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-02, Vol.61 (4), p.1609-1621
Hauptverfasser:	Abd El-Salam, Mohamed, Bastos, Jairo Kenupp, Han, Jing Jing, Previdi, Daniel, Coelho, Eduardo B, Donate, Paulo M, Romero, Michael F, Lieske, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A1 - drug effects Annexin A1 - metabolism Antioxidants Calcium Oxalate - chemistry Cell Adhesion - drug effects Cell Line Crystallization Dogs Drosophila melanogaster Gallic Acid - analogs & derivatives Gallic Acid - chemical synthesis Gallic Acid - chemistry Gallic Acid - pharmacology Madin Darby Canine Kidney Cells - drug effects Madin Darby Canine Kidney Cells - metabolism Malpighian Tubules - chemistry Quinic Acid - analogs & derivatives Quinic Acid - chemical synthesis Quinic Acid - chemistry Quinic Acid - pharmacology Subcellular Fractions - chemistry Subcellular Fractions - metabolism
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