Attenuation of Marek's disease virus by codon pair deoptimization of a core gene

Marek's disease virus (MDV) is an oncogenic alphaherpesvirus of Gallus gallus, the domesticated chicken. Control strategies rely upon vaccination with live attenuated viruses of antigenically similar avian herpesviruses or attenuated strains of MDV. Recent studies in other viruses have shown th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2018-03, Vol.516, p.219-226
Hauptverfasser:	Conrad, Steven J., Silva, Robert F., Hearn, Cari J., Climans, Megan, Dunn, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal viruses atrophy chickens Codon pair bias Codon pair score Deoptimization Gallus gallus genes live vaccines lymphocytes Mardivirus Marek's disease virus MDV mutants neoplasms proteins SAVE Synthetic attenuated virus engineering vaccination viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!