Identification of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamate-nitrostyrene hybrid as potent antiproliferative and apoptotic inducing agent against cervical cancer cell lines

The present study seeks to describe the design and synthesis of six new Michael adducts of (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamate with nitrostyrenes and their in vitro antiproliferative activity against human cervical cancer cell lines [HeLa (HPV 18 positive), CaSki (HPV 16 positive)...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-02, Vol.146, p.621-635
Hauptverfasser:	Laskar, Sujay, Sánchez-Sánchez, Luis, Flores, Sebastián M., López-Muñoz, Hugo, Escobar-Sánchez, María L., López-Ortiz, Manuel, Hernández-Rodríguez, Marcos, Regla, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiproliferative Apoptosis - drug effects Aza Compounds - chemistry Aza Compounds - pharmacology Cell Cycle - drug effects Cell Proliferation - drug effects Dithiocarbamate Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Female HeLa Cells Humans Molecular Structure Necrosis Nitro Compounds - chemistry Nitro Compounds - pharmacology Nitrostyrene Pro-apoptotic Structure-Activity Relationship Styrene - chemistry Styrene - pharmacology Thiocarbamates - chemistry Thiocarbamates - pharmacology Tumor Cells, Cultured Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology
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