Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood
BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patien...
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| Veröffentlicht in: | Human reproduction (Oxford) 2007-12, Vol.22 (12), p.3215-3222 |
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| creator | van Beek, Robert D. Smit, Marij van den Heuvel-Eibrink, Marry M. de Jong, Frank H. Hakvoort-Cammel, Friederike G. van den Bos, Cor van den Berg, Henk Weber, Rob F.A. Pieters, Rob de Muinck Keizer-Schrama, Sabine M.P.F. |
| description | BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patients treated from 1974–1998 for childhood Hodgkin’s lymphoma with combination chemotherapy ABVD or EBVD (adriamycin/epirubicin, bleomycin, vinblastine, dacarbazine) with or without MOPP (mechlorethamine, vincristin, prednisone, procarbazine) with the intention to avoid radiotherapy. These men were studied 15.5 years (range 5.6–30.2 years) after cessation of therapy. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone, sex hormone-binding globulin (SHBG), sperm concentration and sperm DNA integrity were determined. RESULTS In men treated with MOPP, median FSH and LH were significantly increased (P < 0.001) and inhibin B (17.5 versus 143 ng/l; P < 0.001) and sperm concentration (1.05 versus 49.5 × 106/ml; P < 0.05) were significantly decreased compared with patients treated without MOPP. The number of MOPP courses was significantly correlated with FSH and inhibin B levels. Only inhibin B showed an independent correlation with sperm concentration (r = 0.86; P < 0.001). CONCLUSIONS The use of MOPP chemotherapy causes permanent gonadal damage in the far majority of male survivors of childhood Hodgkin’s lymphoma and inhibin B is the most valuable serum marker for gonadal function. |
| doi_str_mv | 10.1093/humrep/dem313 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_19988841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/dem313</oup_id><sourcerecordid>19988841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-38ef0e4b7d8f08412593eca31b324e81b5c843cede7b12630711038b35396ff93</originalsourceid><addsrcrecordid>eNqF0c1u1DAQB3ALgei2cOSKLCQQl1BPnA_7CBXtFiqhioJQL5aTTDZu4zjYicreeAEegNfjSXDJikpcONmyfzMe-U_IE2CvgEl-2M3W43jYoOXA75EVZAVLUp6z-2TF0kIkAAXskf0QrhiLW1E8JHtQSgECyhX5cTp0pjIDfUNNoGEe0Rvn6eTo8cc11YFqGtDPllrtr9HTNl6GiKye3AYHDLEqVlsc6ORRT9j8IWvXbK7N8Ov7z0D7rR07ZzW9MVNH6w6tmzr0etzSZvZm2MQz0zedc80j8qDVfcDHu_WAfDp-e3G0Ts4-nJwevT5L6ixnU8IFtgyzqmxEy0QGaS451ppDxdMMBVR5LTJeY4NlBWnBWQnAuKh4zmXRtpIfkBdL39G7rzOGSVkTaux7PaCbgwIphYiNI3z2D7xysx_ibCoFkCnkKYsoWVDtXQgeWzV6E_9rq4Cp25DUEpJaQor-6a7pXFls7vQulQie74AOte5br4fahDsnJRS5uHUvF-fm8b9v7mY0YcJvf3EMVRUlL3O1_nKp-MX5u_eX55_VCf8NL_67fw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211921520</pqid></control><display><type>article</type><title>Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>van Beek, Robert D. ; Smit, Marij ; van den Heuvel-Eibrink, Marry M. ; de Jong, Frank H. ; Hakvoort-Cammel, Friederike G. ; van den Bos, Cor ; van den Berg, Henk ; Weber, Rob F.A. ; Pieters, Rob ; de Muinck Keizer-Schrama, Sabine M.P.F.</creator><creatorcontrib>van Beek, Robert D. ; Smit, Marij ; van den Heuvel-Eibrink, Marry M. ; de Jong, Frank H. ; Hakvoort-Cammel, Friederike G. ; van den Bos, Cor ; van den Berg, Henk ; Weber, Rob F.A. ; Pieters, Rob ; de Muinck Keizer-Schrama, Sabine M.P.F.</creatorcontrib><description>BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patients treated from 1974–1998 for childhood Hodgkin’s lymphoma with combination chemotherapy ABVD or EBVD (adriamycin/epirubicin, bleomycin, vinblastine, dacarbazine) with or without MOPP (mechlorethamine, vincristin, prednisone, procarbazine) with the intention to avoid radiotherapy. These men were studied 15.5 years (range 5.6–30.2 years) after cessation of therapy. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone, sex hormone-binding globulin (SHBG), sperm concentration and sperm DNA integrity were determined. RESULTS In men treated with MOPP, median FSH and LH were significantly increased (P < 0.001) and inhibin B (17.5 versus 143 ng/l; P < 0.001) and sperm concentration (1.05 versus 49.5 × 106/ml; P < 0.05) were significantly decreased compared with patients treated without MOPP. The number of MOPP courses was significantly correlated with FSH and inhibin B levels. Only inhibin B showed an independent correlation with sperm concentration (r = 0.86; P < 0.001). CONCLUSIONS The use of MOPP chemotherapy causes permanent gonadal damage in the far majority of male survivors of childhood Hodgkin’s lymphoma and inhibin B is the most valuable serum marker for gonadal function.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dem313</identifier><identifier>PMID: 17981817</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biological and medical sciences ; Biomarkers - blood ; Bleomycin - adverse effects ; Child ; Dacarbazine - adverse effects ; Doxorubicin - adverse effects ; Epirubicin - adverse effects ; Fertility ; Follicle Stimulating Hormone - blood ; Gynecology. Andrology. Obstetrics ; Hodgkin Disease - drug therapy ; Hodgkin’s lymphoma ; Humans ; inhibin B ; Inhibins - blood ; long-term follow-up ; Male ; Mechlorethamine - adverse effects ; Medical sciences ; Prednisone - adverse effects ; Procarbazine - adverse effects ; Spermatogenesis ; Time Factors ; Vinblastine - adverse effects ; Vincristine - adverse effects</subject><ispartof>Human reproduction (Oxford), 2007-12, Vol.22 (12), p.3215-3222</ispartof><rights>The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2007</rights><rights>2008 INIST-CNRS</rights><rights>The Author 2007. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-38ef0e4b7d8f08412593eca31b324e81b5c843cede7b12630711038b35396ff93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19916587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17981817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Beek, Robert D.</creatorcontrib><creatorcontrib>Smit, Marij</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M.</creatorcontrib><creatorcontrib>de Jong, Frank H.</creatorcontrib><creatorcontrib>Hakvoort-Cammel, Friederike G.</creatorcontrib><creatorcontrib>van den Bos, Cor</creatorcontrib><creatorcontrib>van den Berg, Henk</creatorcontrib><creatorcontrib>Weber, Rob F.A.</creatorcontrib><creatorcontrib>Pieters, Rob</creatorcontrib><creatorcontrib>de Muinck Keizer-Schrama, Sabine M.P.F.</creatorcontrib><title>Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patients treated from 1974–1998 for childhood Hodgkin’s lymphoma with combination chemotherapy ABVD or EBVD (adriamycin/epirubicin, bleomycin, vinblastine, dacarbazine) with or without MOPP (mechlorethamine, vincristin, prednisone, procarbazine) with the intention to avoid radiotherapy. These men were studied 15.5 years (range 5.6–30.2 years) after cessation of therapy. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone, sex hormone-binding globulin (SHBG), sperm concentration and sperm DNA integrity were determined. RESULTS In men treated with MOPP, median FSH and LH were significantly increased (P < 0.001) and inhibin B (17.5 versus 143 ng/l; P < 0.001) and sperm concentration (1.05 versus 49.5 × 106/ml; P < 0.05) were significantly decreased compared with patients treated without MOPP. The number of MOPP courses was significantly correlated with FSH and inhibin B levels. Only inhibin B showed an independent correlation with sperm concentration (r = 0.86; P < 0.001). CONCLUSIONS The use of MOPP chemotherapy causes permanent gonadal damage in the far majority of male survivors of childhood Hodgkin’s lymphoma and inhibin B is the most valuable serum marker for gonadal function.</description><subject>Adult</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bleomycin - adverse effects</subject><subject>Child</subject><subject>Dacarbazine - adverse effects</subject><subject>Doxorubicin - adverse effects</subject><subject>Epirubicin - adverse effects</subject><subject>Fertility</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Hodgkin’s lymphoma</subject><subject>Humans</subject><subject>inhibin B</subject><subject>Inhibins - blood</subject><subject>long-term follow-up</subject><subject>Male</subject><subject>Mechlorethamine - adverse effects</subject><subject>Medical sciences</subject><subject>Prednisone - adverse effects</subject><subject>Procarbazine - adverse effects</subject><subject>Spermatogenesis</subject><subject>Time Factors</subject><subject>Vinblastine - adverse effects</subject><subject>Vincristine - adverse effects</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAQB3ALgei2cOSKLCQQl1BPnA_7CBXtFiqhioJQL5aTTDZu4zjYicreeAEegNfjSXDJikpcONmyfzMe-U_IE2CvgEl-2M3W43jYoOXA75EVZAVLUp6z-2TF0kIkAAXskf0QrhiLW1E8JHtQSgECyhX5cTp0pjIDfUNNoGEe0Rvn6eTo8cc11YFqGtDPllrtr9HTNl6GiKye3AYHDLEqVlsc6ORRT9j8IWvXbK7N8Ov7z0D7rR07ZzW9MVNH6w6tmzr0etzSZvZm2MQz0zedc80j8qDVfcDHu_WAfDp-e3G0Ts4-nJwevT5L6ixnU8IFtgyzqmxEy0QGaS451ppDxdMMBVR5LTJeY4NlBWnBWQnAuKh4zmXRtpIfkBdL39G7rzOGSVkTaux7PaCbgwIphYiNI3z2D7xysx_ibCoFkCnkKYsoWVDtXQgeWzV6E_9rq4Cp25DUEpJaQor-6a7pXFls7vQulQie74AOte5br4fahDsnJRS5uHUvF-fm8b9v7mY0YcJvf3EMVRUlL3O1_nKp-MX5u_eX55_VCf8NL_67fw</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>van Beek, Robert D.</creator><creator>Smit, Marij</creator><creator>van den Heuvel-Eibrink, Marry M.</creator><creator>de Jong, Frank H.</creator><creator>Hakvoort-Cammel, Friederike G.</creator><creator>van den Bos, Cor</creator><creator>van den Berg, Henk</creator><creator>Weber, Rob F.A.</creator><creator>Pieters, Rob</creator><creator>de Muinck Keizer-Schrama, Sabine M.P.F.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7ST</scope><scope>7T5</scope><scope>7U6</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20071201</creationdate><title>Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood</title><author>van Beek, Robert D. ; Smit, Marij ; van den Heuvel-Eibrink, Marry M. ; de Jong, Frank H. ; Hakvoort-Cammel, Friederike G. ; van den Bos, Cor ; van den Berg, Henk ; Weber, Rob F.A. ; Pieters, Rob ; de Muinck Keizer-Schrama, Sabine M.P.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-38ef0e4b7d8f08412593eca31b324e81b5c843cede7b12630711038b35396ff93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bleomycin - adverse effects</topic><topic>Child</topic><topic>Dacarbazine - adverse effects</topic><topic>Doxorubicin - adverse effects</topic><topic>Epirubicin - adverse effects</topic><topic>Fertility</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Hodgkin’s lymphoma</topic><topic>Humans</topic><topic>inhibin B</topic><topic>Inhibins - blood</topic><topic>long-term follow-up</topic><topic>Male</topic><topic>Mechlorethamine - adverse effects</topic><topic>Medical sciences</topic><topic>Prednisone - adverse effects</topic><topic>Procarbazine - adverse effects</topic><topic>Spermatogenesis</topic><topic>Time Factors</topic><topic>Vinblastine - adverse effects</topic><topic>Vincristine - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Beek, Robert D.</creatorcontrib><creatorcontrib>Smit, Marij</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M.</creatorcontrib><creatorcontrib>de Jong, Frank H.</creatorcontrib><creatorcontrib>Hakvoort-Cammel, Friederike G.</creatorcontrib><creatorcontrib>van den Bos, Cor</creatorcontrib><creatorcontrib>van den Berg, Henk</creatorcontrib><creatorcontrib>Weber, Rob F.A.</creatorcontrib><creatorcontrib>Pieters, Rob</creatorcontrib><creatorcontrib>de Muinck Keizer-Schrama, Sabine M.P.F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Sustainability Science Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Beek, Robert D.</au><au>Smit, Marij</au><au>van den Heuvel-Eibrink, Marry M.</au><au>de Jong, Frank H.</au><au>Hakvoort-Cammel, Friederike G.</au><au>van den Bos, Cor</au><au>van den Berg, Henk</au><au>Weber, Rob F.A.</au><au>Pieters, Rob</au><au>de Muinck Keizer-Schrama, Sabine M.P.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2007-12-01</date><risdate>2007</risdate><volume>22</volume><issue>12</issue><spage>3215</spage><epage>3222</epage><pages>3215-3222</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND The aim of this study was to evaluate the long-term gonadal sequelae after treatment for childhood Hodgkin’s lymphoma with combination chemotherapy, using up to date fertility parameters and andrological evaluation, including for the first time inhibin B. METHODS There were 56 male patients treated from 1974–1998 for childhood Hodgkin’s lymphoma with combination chemotherapy ABVD or EBVD (adriamycin/epirubicin, bleomycin, vinblastine, dacarbazine) with or without MOPP (mechlorethamine, vincristin, prednisone, procarbazine) with the intention to avoid radiotherapy. These men were studied 15.5 years (range 5.6–30.2 years) after cessation of therapy. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), inhibin B, testosterone, sex hormone-binding globulin (SHBG), sperm concentration and sperm DNA integrity were determined. RESULTS In men treated with MOPP, median FSH and LH were significantly increased (P < 0.001) and inhibin B (17.5 versus 143 ng/l; P < 0.001) and sperm concentration (1.05 versus 49.5 × 106/ml; P < 0.05) were significantly decreased compared with patients treated without MOPP. The number of MOPP courses was significantly correlated with FSH and inhibin B levels. Only inhibin B showed an independent correlation with sperm concentration (r = 0.86; P < 0.001). CONCLUSIONS The use of MOPP chemotherapy causes permanent gonadal damage in the far majority of male survivors of childhood Hodgkin’s lymphoma and inhibin B is the most valuable serum marker for gonadal function.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17981817</pmid><doi>10.1093/humrep/dem313</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Biological and medical sciences Biomarkers - blood Bleomycin - adverse effects Child Dacarbazine - adverse effects Doxorubicin - adverse effects Epirubicin - adverse effects Fertility Follicle Stimulating Hormone - blood Gynecology. Andrology. Obstetrics Hodgkin Disease - drug therapy Hodgkin’s lymphoma Humans inhibin B Inhibins - blood long-term follow-up Male Mechlorethamine - adverse effects Medical sciences Prednisone - adverse effects Procarbazine - adverse effects Spermatogenesis Time Factors Vinblastine - adverse effects Vincristine - adverse effects |
| title | Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin’s lymphoma with chemotherapy during childhood |
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