The fungal biopesticide Metarhizium anisopliae has an adjuvant effect on the allergic response to ovalbumin in mice
The parasitic fungus, Metarhizium anisopliae, is non-pathogenic to humans and licensed for indoor control of cockroach infestation. An important reason for the elimination of this vermin is that sensitisation to cockroaches is associated with asthma. Previously M. anisopliae has been shown to cause...
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| Veröffentlicht in: | Toxicology letters 2006-03, Vol.161 (3), p.219-225 |
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| creator | Instanes, Christine Ward, Marsha D.W. Hetland, Geir |
| description | The parasitic fungus,
Metarhizium anisopliae, is non-pathogenic to humans and licensed for indoor control of cockroach infestation. An important reason for the elimination of this vermin is that sensitisation to cockroaches is associated with asthma. Previously
M. anisopliae has been shown to cause allergic- and asthma-like responses in mice and in the present study we have examined the adjuvant activity of
M. anisopliae on the allergic response to the model allergen ovalbumin (OVA) in a mouse model. Levels of OVA-specific IgE, IgG1 and IgG2a in serum were measured and the weight and cell number of the excised popliteal lymph node were determined. Mice primed with mycelium
+
OVA and boosted with OVA had increased anti-OVA IgE and IgG1 levels compared with mice primed with OVA alone or mycelium. Priming with
M. anisopliae (as mycelium or MACA) increased weight or cell number of the excised PLNs. These results suggest that
M. anisopliae has the ability to increase an allergic response to an allergen and consequently, may worsen allergy in susceptible individuals. |
| doi_str_mv | 10.1016/j.toxlet.2005.09.006 |
| format | Article |
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Metarhizium anisopliae, is non-pathogenic to humans and licensed for indoor control of cockroach infestation. An important reason for the elimination of this vermin is that sensitisation to cockroaches is associated with asthma. Previously
M. anisopliae has been shown to cause allergic- and asthma-like responses in mice and in the present study we have examined the adjuvant activity of
M. anisopliae on the allergic response to the model allergen ovalbumin (OVA) in a mouse model. Levels of OVA-specific IgE, IgG1 and IgG2a in serum were measured and the weight and cell number of the excised popliteal lymph node were determined. Mice primed with mycelium
+
OVA and boosted with OVA had increased anti-OVA IgE and IgG1 levels compared with mice primed with OVA alone or mycelium. Priming with
M. anisopliae (as mycelium or MACA) increased weight or cell number of the excised PLNs. These results suggest that
M. anisopliae has the ability to increase an allergic response to an allergen and consequently, may worsen allergy in susceptible individuals.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2005.09.006</identifier><identifier>PMID: 16216451</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adjuvant effect ; Adjuvants, Immunologic - toxicity ; Allergens - toxicity ; Animals ; Antigens, Fungal - immunology ; Antigens, Fungal - toxicity ; Cockroaches ; Disease Models, Animal ; Female ; Hindlimb ; Hypersensitivity, Immediate - immunology ; IgE ; Immunoglobulin E - blood ; Immunoglobulin G - blood ; Inhalation Exposure ; Lymph Nodes - immunology ; Metarhizium anisopliae ; Mice ; Mice, Inbred BALB C ; Mitosporic Fungi - chemistry ; Mitosporic Fungi - immunology ; Mould ; Organ Size - drug effects ; Ovalbumin - immunology ; Pest Control, Biological ; Pesticides - immunology ; Pesticides - toxicity ; Plant Extracts - immunology</subject><ispartof>Toxicology letters, 2006-03, Vol.161 (3), p.219-225</ispartof><rights>2005 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-317201b60f1a428808ad90bd3d24e2bfb1435add5b4e418305e42459fd21aeee3</citedby><cites>FETCH-LOGICAL-c457t-317201b60f1a428808ad90bd3d24e2bfb1435add5b4e418305e42459fd21aeee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378427405002730$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16216451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Instanes, Christine</creatorcontrib><creatorcontrib>Ward, Marsha D.W.</creatorcontrib><creatorcontrib>Hetland, Geir</creatorcontrib><title>The fungal biopesticide Metarhizium anisopliae has an adjuvant effect on the allergic response to ovalbumin in mice</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>The parasitic fungus,
Metarhizium anisopliae, is non-pathogenic to humans and licensed for indoor control of cockroach infestation. An important reason for the elimination of this vermin is that sensitisation to cockroaches is associated with asthma. Previously
M. anisopliae has been shown to cause allergic- and asthma-like responses in mice and in the present study we have examined the adjuvant activity of
M. anisopliae on the allergic response to the model allergen ovalbumin (OVA) in a mouse model. Levels of OVA-specific IgE, IgG1 and IgG2a in serum were measured and the weight and cell number of the excised popliteal lymph node were determined. Mice primed with mycelium
+
OVA and boosted with OVA had increased anti-OVA IgE and IgG1 levels compared with mice primed with OVA alone or mycelium. Priming with
M. anisopliae (as mycelium or MACA) increased weight or cell number of the excised PLNs. These results suggest that
M. anisopliae has the ability to increase an allergic response to an allergen and consequently, may worsen allergy in susceptible individuals.</description><subject>Adjuvant effect</subject><subject>Adjuvants, Immunologic - toxicity</subject><subject>Allergens - toxicity</subject><subject>Animals</subject><subject>Antigens, Fungal - immunology</subject><subject>Antigens, Fungal - toxicity</subject><subject>Cockroaches</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Hindlimb</subject><subject>Hypersensitivity, Immediate - immunology</subject><subject>IgE</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Inhalation Exposure</subject><subject>Lymph Nodes - immunology</subject><subject>Metarhizium anisopliae</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitosporic Fungi - chemistry</subject><subject>Mitosporic Fungi - immunology</subject><subject>Mould</subject><subject>Organ Size - drug effects</subject><subject>Ovalbumin - immunology</subject><subject>Pest Control, Biological</subject><subject>Pesticides - immunology</subject><subject>Pesticides - toxicity</subject><subject>Plant Extracts - immunology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFK5DAUhoO46Oj6BrLkyrupSZq0zY0g4q6CsjfudUiTUydD2nSTdHD36Y3MgHdC4BD4zn_4P4QuKakooc31tsrhzUOuGCGiIrIipDlCK9q1cl3TRh6jFanbbs1Zy0_RWUpbUgjeiBN0ShtGGy7oCqWXDeBhmV61x70LM6TsjLOAnyHruHH_3TJiPbkUZu804I1O5Yu13S47PWUMwwAm4zDhXIK09xBfncER0hymBDgHHHba98voJlze6Ax8R98G7RNcHOY5-vPz_uXuYf30-9fj3e3T2nDR5lKiZYT2DRmo5qzrSKetJL2tLePA-qGnvBbaWtFz4LSriQDOuJCDZVQDQH2Orva5cwx_l9JMjS4Z8F5PEJakqJSdkKIrIN-DJoaUIgxqjm7U8Z-iRH3IVlu1l60-ZCsiVVFZ1n4c8pd-BPu5dLBbgJs9AKXlzkFUyTiYDFgXizVlg_v6wjsw-ZRk</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Instanes, Christine</creator><creator>Ward, Marsha D.W.</creator><creator>Hetland, Geir</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7U7</scope><scope>C1K</scope><scope>M7N</scope></search><sort><creationdate>20060301</creationdate><title>The fungal biopesticide Metarhizium anisopliae has an adjuvant effect on the allergic response to ovalbumin in mice</title><author>Instanes, Christine ; Ward, Marsha D.W. ; Hetland, Geir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-317201b60f1a428808ad90bd3d24e2bfb1435add5b4e418305e42459fd21aeee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adjuvant effect</topic><topic>Adjuvants, Immunologic - toxicity</topic><topic>Allergens - toxicity</topic><topic>Animals</topic><topic>Antigens, Fungal - immunology</topic><topic>Antigens, Fungal - toxicity</topic><topic>Cockroaches</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Hindlimb</topic><topic>Hypersensitivity, Immediate - immunology</topic><topic>IgE</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Inhalation Exposure</topic><topic>Lymph Nodes - immunology</topic><topic>Metarhizium anisopliae</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitosporic Fungi - chemistry</topic><topic>Mitosporic Fungi - immunology</topic><topic>Mould</topic><topic>Organ Size - drug effects</topic><topic>Ovalbumin - immunology</topic><topic>Pest Control, Biological</topic><topic>Pesticides - immunology</topic><topic>Pesticides - toxicity</topic><topic>Plant Extracts - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Instanes, Christine</creatorcontrib><creatorcontrib>Ward, Marsha D.W.</creatorcontrib><creatorcontrib>Hetland, Geir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Instanes, Christine</au><au>Ward, Marsha D.W.</au><au>Hetland, Geir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The fungal biopesticide Metarhizium anisopliae has an adjuvant effect on the allergic response to ovalbumin in mice</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>161</volume><issue>3</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>The parasitic fungus,
Metarhizium anisopliae, is non-pathogenic to humans and licensed for indoor control of cockroach infestation. An important reason for the elimination of this vermin is that sensitisation to cockroaches is associated with asthma. Previously
M. anisopliae has been shown to cause allergic- and asthma-like responses in mice and in the present study we have examined the adjuvant activity of
M. anisopliae on the allergic response to the model allergen ovalbumin (OVA) in a mouse model. Levels of OVA-specific IgE, IgG1 and IgG2a in serum were measured and the weight and cell number of the excised popliteal lymph node were determined. Mice primed with mycelium
+
OVA and boosted with OVA had increased anti-OVA IgE and IgG1 levels compared with mice primed with OVA alone or mycelium. Priming with
M. anisopliae (as mycelium or MACA) increased weight or cell number of the excised PLNs. These results suggest that
M. anisopliae has the ability to increase an allergic response to an allergen and consequently, may worsen allergy in susceptible individuals.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>16216451</pmid><doi>10.1016/j.toxlet.2005.09.006</doi><tpages>7</tpages></addata></record> |
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| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adjuvant effect Adjuvants, Immunologic - toxicity Allergens - toxicity Animals Antigens, Fungal - immunology Antigens, Fungal - toxicity Cockroaches Disease Models, Animal Female Hindlimb Hypersensitivity, Immediate - immunology IgE Immunoglobulin E - blood Immunoglobulin G - blood Inhalation Exposure Lymph Nodes - immunology Metarhizium anisopliae Mice Mice, Inbred BALB C Mitosporic Fungi - chemistry Mitosporic Fungi - immunology Mould Organ Size - drug effects Ovalbumin - immunology Pest Control, Biological Pesticides - immunology Pesticides - toxicity Plant Extracts - immunology |
| title | The fungal biopesticide Metarhizium anisopliae has an adjuvant effect on the allergic response to ovalbumin in mice |
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