Smad3-dependent nuclear translocation of beta -catenin is required for TGF- beta 1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells

Smad3-dependent nuclear translocation of beta -catenin is required for TGF- beta 1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells

Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we describe the functional role of a novel form of cross-talk between the transforming growth factor beta 1 (TGF- beta 1) and Wnt signaling pathways in regulatin...

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Veröffentlicht in:Genes & development 2006-03, Vol.20 (6), p.666-674
Hauptverfasser: Jian, Hongyan, Shen, Xing, Liu, Irwin, Semenov, Mikhail, He, Xi, Wang, Xiao-Fan
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container_issue 6
container_start_page 666
container_title Genes & development
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creator Jian, Hongyan
Shen, Xing
Liu, Irwin
Semenov, Mikhail
He, Xi
Wang, Xiao-Fan
description Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we describe the functional role of a novel form of cross-talk between the transforming growth factor beta 1 (TGF- beta 1) and Wnt signaling pathways in regulating the activities of human MSCs. We show that TGF- beta 1 induces rapid nuclear translocation of beta -catenin in MSCs in a Smad3-dependent manner. Functionally, this pathway is required for the stimulation of MSC proliferation and the inhibition of MSC osteogenic differetiation by TGF- beta 1, likely through the regulation of specific downstream target genes. These results provide evidence for a new mode of cooperation between the TGF- beta and Wnt signaling pathways in this specific cellular context and suggest a potentially important role for this distinct signaling pathway in the control of self-renewal and differentiation of a specific type of MSCs.
doi_str_mv 10.1101/gad.1388806
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title Smad3-dependent nuclear translocation of beta -catenin is required for TGF- beta 1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
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