Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells

Efficient handling of oxidative stress is critical for the survival of organisms. The orphan nuclear receptor pregnane X receptor (PXR) is important in xenobiotic detoxification through its regulation of phase I and phase II drug-metabolizing/detoxifying enzymes and transporters. In this study we un...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2006-02, Vol.20 (2), p.279-290
Hauptverfasser:	Gong, Haibiao, Singh, Shivendra V, Singh, Sharda P, Mu, Ying, Lee, Jung Hoon, Saini, Simrat P. S, Toma, David, Ren, Songrong, Kagan, Valerian E, Day, Billy W, Zimniak, Piotr, Xie, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Chloramphenicol O-Acetyltransferase - metabolism Colonic Neoplasms - metabolism Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Down-Regulation Fatty Acid-Binding Proteins - genetics Female Glutathione - metabolism Glutathione Transferase - metabolism Humans Isoenzymes - metabolism Kelch-Like ECH-Associated Protein 1 Liver - cytology Liver - drug effects Liver - metabolism Mice Mice, Transgenic NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress Paraquat - toxicity Promoter Regions, Genetic Rats Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Steroid - agonists Receptors, Steroid - metabolism Sex Factors Superoxide Dismutase - metabolism
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