Steady-State Pharmacokinetics of Emtricitabine and Tenofovir Disoproxil Fumarate Administered Alone and in Combination in Healthy Volunteers

The approved antiretroviral drugs, emtricitabine and tenofovir disoproxil fumarate, were considered good candidates for a fixed‐dose combination product that could be administered as a single pill once daily (qd), thereby simplifying existing treatment regimens and promoting patient adherence. As bo...

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Veröffentlicht in:	Journal of clinical pharmacology 2007-06, Vol.47 (6), p.751-759
Hauptverfasser:	Blum, M. Robert, Chittick, Gregory E., Begley, John A., Zong, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - adverse effects Adenine - analogs & derivatives Adenine - pharmacokinetics Adult Analysis Anti-Retroviral Agents - administration & dosage Anti-Retroviral Agents - adverse effects Anti-Retroviral Agents - pharmacokinetics Area Under Curve Cross-Over Studies Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics drug interaction Drug interactions Drug Therapy, Combination Emtricitabine Female Highly active antiretroviral therapy Humans Male Organophosphonates - administration & dosage Organophosphonates - adverse effects Organophosphonates - pharmacokinetics pharmacokinetics renal elimination Tenofovir tenofovir DF
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