Identification of crystallin family proteins in vitreous body in rat endotoxin-induced uveitis: Involvement of crystallin truncation in uveitis pathogenesis

Endotoxin‐induced uveitis (EIU) is an animal model of acute ocular inflammation. To characterize the mechanism of EIU, we analyzed the infiltration of proteins in the vitreous bodies of rats with EIU and normal rats using 2‐DE and micro LC/LC‐MS/MS. Twenty spots were identified in vitreous bodies of...

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Veröffentlicht in:	Proteomics (Weinheim) 2006-06, Vol.6 (11), p.3436-3444
Hauptverfasser:	Bahk, Song-Chul, Lee, Sook-Hee, Jang, Jung-Un, Choi, Chang-Uk, Lee, Bok-Soo, Chae, Soo-Cheon, Song, Hye-Jin, Park, Zee-Yong, Yang, Yun-Sik, Chung, Hun-Taeg
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Crystallin Crystallins - metabolism Electrophoresis, Gel, Two-Dimensional Endotoxin-induced uveitis Fundamental and applied biological sciences. Psychology Lipopolysaccharides Male Mass Spectrometry Medical sciences Miscellaneous Molecular Sequence Data Ophthalmology Proteins Proteome - metabolism Rats Rats, Inbred Lew Truncation Two-dimensional electrophoresis Uvea diseases Uveitis - chemically induced Uveitis - metabolism Vitreous Body - metabolism
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