A phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer

Pancreatic cancer is amongst the most chemoresistant malignancies. Expression of the cyclooxygenase-2 (COX-2) enzyme plays a major role in tumor progression and resistance to therapy. A Phase II study was undertaken to determine the effect of gemcitabine by fixed-dose rate infusion (FDR), cisplatin...

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Veröffentlicht in:	Investigational new drugs 2005-12, Vol.23 (6), p.583-590
Hauptverfasser:	El-Rayes, Basil F, Zalupski, Mark M, Shields, Anthony F, Ferris, Ann Marie, Vaishampayan, Ulka, Heilbrun, Lance K, Venkatramanamoorthy, Raghu, Adsay, Volkan, Philip, Philip A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - secondary Adult Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer therapies Celecoxib Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Creatinine Cyclooxygenase Inhibitors - administration & dosage Cyclooxygenase Inhibitors - adverse effects Cytotoxicity Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Drug dosages Female Humans Liver Neoplasms - drug therapy Liver Neoplasms - secondary Male Metastasis Middle Aged Neutropenia Neutrophils Oncology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Pyrazoles - administration & dosage Pyrazoles - adverse effects Response rates Sulfonamides - administration & dosage Sulfonamides - adverse effects Survival Analysis Toxicity Ulcers
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